INTRODUCTION
Non-Hodgkin’s lymphomas (NHL) comprises 70–80% of all lymphoma
cases.1 They are generally found in lymph nodes or
other lymphoid tissue like the spleen and bone
marrow.2 However, around 20–24% of NHL cases are
extranodal and mostly originate from areas like the gastrointestinal
tract, lungs, central nervous system, skin, thyroid, and salivary
glands.
Although the secondary involvement of the female genital tract,
especially the ovaries is common, primary genital tract lymphomas are
exceptionally rare, accounting for less than 0.5% of genital cancers
and 1.5% of all NHL cases. These tumors are anatomically reported in
the following order of prevalence: ovary (49%), uterus (29%),
fallopian tube (11%), vagina (7%), and vulva
(4%).2,3
Diffuse large B cell lymphoma (DLBCL) is a subtype of non-Hodgkin
lymphoma that comprises around 30% of total NHL cases. DLBCL can be
further classified into three subtypes; germinal center B-cell,
activated B-cell, and unclassified subtype.
So far only a couple of dozen cases of DLBCL of vulva are reported in
the medical literature and is hence a very rare
entity.4
We present a rare case of DLBCL of the vulva in a 78-year-old elderly
patient.