REFERENCES
1. Sehn LH, Salles G. Diffuse Large B-Cell Lymphoma. N Engl J Med . 2021;384(9):842-858. doi:10.1056/NEJMra20276122. M S, A M, S C, et al. Conservative management in primary genital lymphomas: the role of chemotherapy. Gynecol Oncol . 2007;104(2). doi:10.1016/j.ygyno.2006.08.0243. Bagella MP, Fadda G, Cherchi PL. Non-Hodgkin lymphoma: a rare primary vulvar localization. Eur J Gynaecol Oncol . 1990;11(2):153-156.4. Ye AL, Willis MS, Link BK, Naridze RL, Syrbu SI, Liu V. Primary diffuse large B cell lymphoma of the vulva—Two new cases of a rare entity and review of the literature.JAAD Case Rep . 2018;4(9):962-967. doi:10.1016/j.jdcr.2018.06.0235. Vang R, Medeiros LJ, Fuller GN, Sarris AH, Deavers M. Non-Hodgkin’s Lymphoma Involving the Gynecologic Tract: A Review of 88 Cases: Adv Anat Pathol . 2001;8(4):200-217. doi:10.1097/00125480-200107000-000026. Shetty AS, Menias CO. MR Imaging of Vulvar and Vaginal Cancer. Magn Reson Imaging Clin N Am . 2017;25(3):481-502. doi:10.1016/j.mric.2017.03.0137. Onyiuke I, Kirby AB, McCarthy S. Primary gynecologic lymphoma: imaging findings.AJR Am J Roentgenol . 2013;201(4):W648-655. doi:10.2214/AJR.12.89078. Choi WWL, Weisenburger DD, Greiner TC, et al. A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy. Clin Cancer Res Off J Am Assoc Cancer Res . 2009;15(17):5494-5502. doi:10.1158/1078-0432.CCR-09-01139. Riedell PA, Smith SM. Double hit and double expressors in lymphoma: Definition and treatment. Cancer . 2018;124(24):4622-4632. doi:10.1002/cncr.3164610. Cho J. Basic immunohistochemistry for lymphoma diagnosis. Blood Res . 2022;57(Suppl 1):55-61. doi:10.5045/br.2022.202203711. Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.N Engl J Med . 2002;346(4):235-242. doi:10.1056/NEJMoa01179512. Clemente N, Alessandrini L, Rupolo M, et al. Primary Non-Hodgkin’s Lymphoma of the Vulva: A Case Report and Literature Review.Medicine (Baltimore) . 2016;95(10):e3041. doi:10.1097/MD.000000000000304113. Harris NL, Scully RE. Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. A clinicopathologic analysis of 27 cases. Cancer . 1984;53(11):2530-2545. doi:10.1002/1097-0142(19840601)53:11<2530::aid-cncr2820531127>3.0.co;2-j14. Vang R, Medeiros LJ, Ha CS, Deavers M. Non-Hodgkin’s lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol Off J U S Can Acad Pathol Inc . 2000;13(1):19-28. doi:10.1038/modpathol.388000515. Stroh EL, Besa PC, Cox JD, Fuller LM, Cabanillas FF. Treatment of patients with lymphomas of the uterus or cervix with combination chemotherapy and radiation therapy.Cancer . 1995;75(9):2392-2399. doi:10.1002/1097-0142(19950501)75:9<2392::aid-cncr2820750932>3.0.co;2-yFIGURE LEGENDS
Figure 1: Hematoxylin and eosin-stained section show discohesive sheets of atypical lymphoid cells have large nucleus, irregular nuclear contours, conspicuous nucleoli and scant cytoplasm. Mitosis noted. (400x)
Figure 2a: IHC shows tumor cells are positive for BCL2
Figure 2b: IHC shows tumor cells are positive for CD20
Figure 2c: IHC shows tumor cells are negative for Ki67