Pre-eclampsia:
There were 5 eligible studies for inclusion in the meta-analysis for pre-eclampsia. This included data on 1175 pregnant women treated with biologics and 1017 disease matched controls (Table 2). In the treated group the percentage of pre-eclampsia was 1% (95% CI 0.01 to 0.02) and the disease matched control 1% (0.00 to 0.01) (Figure S11). No differences were observed in proportions between disease matched compared with disease treated women (p=0.193; Table S2).