Methods
This review was performed according to an a-priori -designed protocol recommended for systematic reviews and meta-analysis.13 Maternal and fetal systematic review protocols were prospectively registered on PROSPERO CRD4201707072 and CRD42020185926. The systematic review was based on the following PICO requirements; Population: Pregnant women with a diagnosis of CID. Intervention/Exposure: Treatment with Biologic medication. Comparison: Pregnant women with a diagnosis of CID without treatment with biologics and a CID free population. Outcomes: fetal outcomes included congenital malformations, preterm delivery, severe neonatal infection, low birth weight and small for gestational age. Maternal outcomes included severe maternal infection, miscarriage and pre-eclampsia.