Miscarriage
The data available on miscarriage included 15 studies with 9368
pregnancies. There were 2708 pregnancies in women treated with biologics
in pregnancy (Table 2). The proportion of miscarriage in the biologics
treated group was 13% (95% CI 0.10 to 0.15), the proportion of
miscarriage in the disease matched group was 8% (0.04 to 0.11) and in
the disease free group 11% (0.03 to 0.19) (Figure S10). There was no
significant difference in proportions between disease matched compared
with disease treated women (p=0.078), or in disease free compared with
disease treated women comparison (p=0.631; Table S2). One study was
excluded from the analysis, they had no difference in their miscarriage
rate across their treated and untreated groups of 3%, but a rate much
lower than all other included studies20. Subgroup
analysis revealed no difference in groups when focusing on anti-TNF-α
studies only (results not shown).