Search methodology
The search strategy was developed with librarian assistance and was carried out through PubMed and EMBASE search engines to identify peer reviewed published papers relating to the association between biologics use for CID in pregnancy and the risk of maternal and neonatal outcomes. Searches were conducted in accordance with the PRISMA guidelines (Preferred Reporting Items for Systematic Review and Meta-analysis).14 PubMed and EMBASE searches were conducted through January 1998 - April 2020 by two reviewers (LOB, SA), and updated again July 2021. Full search terms can be found in the Appendix. Bibliographies of included studies were also searched for additional studies eligible for inclusion. Titles and abstracts of studies retrieved from each database were stored and managed in Endnote reference manager. Three review authors (LOB, SA, AOS) reviewed titles and abstracts, obtaining full text as required.