Results
The search for fetal outcomes produced 1887 titles, after exclusion for duplicates and ineligible studies, 35 studies were eligible and 33 were included in the meta-analysis (Figure S1). The initial search for maternal outcomes produced 2104 results after exclusion for duplicates and ineligible studies, 34 were suitable for inclusion and 25 studies were included in the maternal outcome meta-analysis (Figure S2).
Overall, there were 35 individual observational studies included in the meta-analysis, 24 cohort studies and 11 case series fulfilling the inclusion criteria. This review contains a total of 11172 pregnancies exposed to biologics, 39290 disease matched controls and 2892933 chronic inflammatory disease free pregnancies used for the meta-analysis. The addition of the peer reviewed case series added 2653 women exposed to biologics in this meta-analysis.