Results
The search for fetal outcomes produced 1887 titles, after exclusion for
duplicates and ineligible studies, 35 studies were eligible and 33 were
included in the meta-analysis (Figure S1). The initial search for
maternal outcomes produced 2104 results after exclusion for duplicates
and ineligible studies, 34 were suitable for inclusion and 25 studies
were included in the maternal outcome meta-analysis (Figure S2).
Overall, there were 35 individual observational studies included in the
meta-analysis, 24 cohort studies and 11 case series fulfilling the
inclusion criteria. This review contains a total of 11172 pregnancies
exposed to biologics, 39290 disease matched controls and 2892933 chronic
inflammatory disease free pregnancies used for the meta-analysis. The
addition of the peer reviewed case series added 2653 women exposed to
biologics in this meta-analysis.