References
1. Lisnevskaia L, Murphy G, Isenberg D. Systemic lupus erythematosus.Lancet 2014; 384 :1878-88.
2. Zharkova O, Celhar T, Cravens PD, Satterthwaite AB, Fairhurst AM,
Davis LS. Pathways leading to an immunological disease: systemic lupus
erythematosus. Rheumatology 2017; 56 :i55-66.
3. You M, Dong G, Li F, Ma F, Ren J, Xu Y, Yue H, Tang R, Ren D, Hou Y.
Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent
manner in B cells. Cell Mol Immunol 2017; 14 :192-202.
4. Dörner T, Giesecke C, Lipsky PE. Mechanisms of B cell autoimmunity in
SLE. Arthritis Res Ther 2011; 13 :243.
5. Kotzin BL. Systemic lupus erythematosus. Cell 1996;85 :303.
6. Alexander JJ, Jacob A, Chang A, Quigg RJ, Jarvis JN. Double negative
T cells, a potential biomarker for systemic lupus erythematosus.Precision Clin Med 2020; 3 :34-43.
7. Chesnutt MS, Finck BK, Killeen N, Connolly MK, Goodman H, Wofsy D.
Enhanced lymphoproliferation and diminished autoimmunity in
CD4-deficient MRL/lpr mice. Clin Immunol Immunopathol 1998;87 :23-32.
8. Nagasu A, Mukai T, Iseki M, Kawahara K, Tsuji S, Nagasu H, Ueki Y,
Ishihara K, Kashihara N, Morita Y. Sh3bp2 Gain-of-function mutation
ameliorates lupus phenotypes in B6.MR-Faslpr mice.Cells 2019; 8 :402.
9. Brandt D, Hedrich CM. TCRαβ + CD3 + CD4 CD8 (double negative) T cells
in autoimmunity. Autoimmun Rev 2018; 17 :422-30.
10. Martina MN, Noel S, Saxena A, Rabb H, Hamad AR. Double negative (DN)
αβ T cells: misperception and overdue recognition. Immunol Cell
Biol 2015; 93 :305.
11. Shaltout AS, Sayed D, Badary MS, Nafee AM, El Zohri MH, Bakry R,
Ahmed SH. Effect of IL6 and IL23 on double negative T cells and anti
ds-DNA in systemic lupus erythematosus patients. Hum Immunol2016; 77 :937-43.
12. Seagal J, Leider N, Wildbaum G, Karin N, Melamed D. Increased plasma
cell frequency and accumulation of abnormal syndecan-1plus T-cells in
Igmu-deficient/lpr mice. Int Immunol 2003; 15 :1045-52.
13. Mohamood AS, Bargatze D, Xiao Z, Jie C, Yagita H, Ruben D, Watson J,
Chakravarti S, Schneck JP, Hamad AR. Fas-mediated apoptosis regulates
the composition of peripheral αβ T cell repertoire by constitutively
purging out double negative T cells. Plos One 2008;3 :e3465.
14. Liu L, Takeda K, Akkoyunlu M. Disease stage-specific pathogenicity
of CD138 (Syndecan 1)-expressing T Cells in systemic lupus
erythematosus. Front Immunol 2020; 11 :01569.
15. Couchman JR. Syndecans: proteoglycan regulators of cell-surface
microdomains? Nature Rev Mol Cell Biol 2003; 4 :926-37.
16 Lu LD, Stump KL, Wallace NH, Dobrzanski P, Serdikoff C, Gingrich DE,
Dugan BJ, Angeles TS, Albom MS, Mason JL, Ator MA, Dorsey BD, Ruggeri
BA, Seavey MM. Depletion of autoreactive plasma cells and treatment of
lupus nephritis in mice using CEP-33779, a novel, orally active,
selective inhibitor of JAK2. J Immunol 2011;187 :3840-53.
17. Calame KL. Plasma cells: finding new light at the end of B cell
development. Nat Immunol 2001; 2 :1103-08.
18. Pan Z, Chen M, Zhang Q, et al. CD3-positive plasmablastic B-cell
neoplasms: a diagnostic pitfall. Mod Pathol 2018;31 :718-31.
19. Getachew Y, Cusimano FA, James LP, Thiele DL. The role of
intrahepatic CD3 +/CD4 /CD8 double negative T (DN T) cells in enhanced
acetaminophen toxicity. Toxicol Appl Pharmacol 2014;280 :264-71.
20. Benihoud K, Bonardelle D, Bobé P, Kiger N. MRL/lpr CD4- CD8- and
CD8+ T cells, respectively, mediate Fas-dependent and perforin cytotoxic
pathways. Eur J Immunol 1997; 27 :415-20.
21. Hidalgo Y, Núñez S, Fuenzalida MJ, Flores-Santibáñez F, Sáez PJ,
Dorner J, Lennon-Dumenil AM, Martínez V, Zorn E, Rosemblatt M, Sauma D,
Bono MR. Thymic B cells promote germinal center-like structures and the
expansion of follicular helper T cells in lupus-prone mice. Front
Immunol 2020; 11 :696.
22. Menon M, Blair PA, Isenberg DA, Mauri C. A regulatory feedback
between plasmacytoid dendritic cells and regulatory B cells is aberrant
in systemic lupus erythematosus. Immunity 2016;44 :683-97.
23. Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S,
Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J,
Cheng X, Sun SC, Xiao Y. Peli1 negatively regulates noncanonical NF-κB
signaling to restrain systemic lupus erythematosus. Nat Commun2018; 9 : 1136.
24. Dik WA, Pike-Overzet K, Weerkamp F, de Ridder D, de Haas EF, Baert
MR, van der Spek P, Koster EE, Reinders MJ, van Dongen JJ, Langerak AW,
Staal FJ. New insights on human T cell development by quantitative T
cell receptor gene rearrangement studies and gene expression profiling.J Exp Med 2005; 201 :1715-23.
25. Anderson G, Jenkinson EJ. Lymphostromal interactions in thymic
development and function. Nat Rev Immunol 2001; 1 :31.
26. Trimble LA, Prince KA, Pestano GA, Daley J, Cantor H. Fas-dependent
elimination of nonselected CD8 cells and lpr disease. J Immunol2002; 168 :4960-7.
27. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S.
Lymphoproliferation disorder in mice explained by defects in Fas antigen
that mediates apoptosis. Nature 1992; 356 :314-7.
28. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and
expression of the fas ligand, a novel member of the tumor necrosis
factor family. Cell 1993; 75 :1169-78.
29. Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the
immunopathogenesis of systemic lupus erythematosus. Nat Rev
Rheumatol 2016; 12 :716-30.
30. Laurent L, Le Fur A, Bloas RL, Néel M, Mary C, Moreau A, Poirier N,
Vanhove B, Fakhouri F. Prevention of lupus nephritis development in
NZB/NZW mice by selective blockade of CD28. Eur J Immunol 2017;47 :1368-76.
31. Corneth OBJ, Schaper F, Luk F, Asmawidjaja PS, Mus AMC, Horst G,
Heeringa P, Hendriks RW, Westra J, Lubberts E. Lack of IL-17 receptor A
signaling aggravates lymphoproliferation in C57BL/6 lpr mice. Sci
Rep 2019; 9 :4032.
32. Zhou T, Bluethmann H, Eldridge J, Berry K, Mountz JD. Origin of
CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor
beta transgenic mouse. J Immunol 1993; 150 :3651-67.
33. Shirai T, Abe M, Yagita H, Okumura K, Morse HC. The expanded
populations of CD4-CD8- T cell receptor alpha/beta+ T cells associated
with the lpr and gld mutations are CD2. J Immunol 1990;144 :3756-61.
34. Giese T, Allison JP, Davidson WF. Functionally anergic lpr and gld
B220+ T cell receptor (TCR)-alpha/beta+ double-negative T cells express
CD28 and respond to costimulation with phorbol myristate acetate and
antibodies to CD28 and the TCR. J Immunol 1993;151 :597-609.
35. Merino R, Fossati L, Iwamoto M, Takahashi S, Lemoine R, Ibnou-Zekri
N, Pugliatti L, Merino J, Izui S. Effect of long-term anti-CD4 or
anti-CD8 treatment on the development of lpr CD4- CD8- double negative T
cells and of the autoimmune syndrome in MRL-lpr/lpr mice. J
Autoimmun 1995; 8 :33-45.
36. Ohteki T, Iwamoto M, Izui S, MacDonald HR. Reduced development of
CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice
lacking major histocompatibility complex class I molecules. Eur J
Immunol 1995; 25 :37-41.
37. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE,
Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in
patients with systemic lupus erythematosus produce IL-17 and infiltrate
the kidneys. J Immunol 2008; 181 :8761-6.
38. Grishkan IV, Ntranos A, Calabresi PA, Gocke AR. Helper T cells
down-regulate CD4 expression upon chronic stimulation giving rise to
double-negative T cells. Cell Immunol 2013; 284 :68-74.
39 Zhang D, Yang W, Degauque N, Tian Y, Mikita A, Zheng XX. New
differentiation pathway for double-negative regulatory T cells that
regulates the magnitude of immune responses. Blood 2007;109 :4071-9.
40. Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M,
Kyttaris VC, Tsokos GC. cAMP-responsive element modulator α (CREMα)
trans-represses the transmembrane glycoprotein CD8 and contributes to
the generation of CD3+CD4-CD8- T cells in health and disease. J
Biol Chem 2013; 288 :31880-7.
41. Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez
Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC. cAMP responsive
element modulator (CREM) α mediates chromatin remodeling of CD8 during
the generation of CD3+ CD4- CD8- T cells. J Biol Chem 2014;289 :2361-70.
42. Li H, Adamopoulos IE, Moulton VR, et al. Systemic lupus
erythematosus favors the generation of IL-17 producing double negative T
cells. Nat Commun 2020; 11 :2859.
43. Sandhu V, Quan M. SLE and serum complement: causative, concomitant
or coincidental? Open Rheumatol J 2017; 11 :113-22.
44. Tshilela KA, Ikeuchi H, Matsumoto T, Kuroiwa T, Sakurai N, Sakairi
T, Kaneko Y, Maeshima A, Hiromura K, Nojima Y. Glomerular cytokine
expression in murine lupus nephritis. Clin Exp Nephrol 2016;20 :23-9.
45. Selvaraja M, Abdullah M, Arip M, Chin VK, Shah A, Amin Nordin S.
Elevated interleukin-25 and its association to Th2 cytokines in systemic
lupus erythematosus with lupus nephritis. PloS One 2019;14 :e0224707.
46. Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M. AVEMAR administration
interferes with the Th2 response in experimental SLE and promotes
amelioration of the disease. Lupus 2001; 10 :622-7.
47. Tan W, Gu Z, Leng J, Zou X, Chen H, Min F, Zhou W, Zhang L, Li G.
Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone
marrow-derived mesenchymal stem cells in patients with systemic lupus
erythematosus. Biomed Pharmacother 2019; 118 :109313.
48. Balomenos D, Rumold R, Theofilopoulos AN. Interferon-gamma is
required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.J Clin Invest 1998; 101 :364-71.
49. Juvet SC, Han M, Vanama R, Joe B, Kim EY, Zhao FL, Jeon C, Adeyi O,
Zhang L. Autocrine IFNɣ controls the regulatory function of
lymphoproliferative double negative T cells. PLoS One 2012;7 :e47732.
50. Tang X, Li W, Wen X, Zhang Z, Chen W, Yao G, Chen H, Wang D, Shi S,
Sun L. Transplantation of dental tissue-derived mesenchymal stem cells
ameliorates nephritis in lupus mice. Ann Transl Med 2019;7 :132.
51. Chodisetti SB, Fike AJ, Domeier PP, Singh H, Choi NM, Corradetti C,
Kawasawa YI, Cooper TK, Caricchio R, Rahman ZSM. Type II but not type I
IFN signaling is indispensable for TLR7-promoted development of
autoreactive B cells and systemic autoimmunity. J Immunol 2020;204 :796-809.
52. Zhang X, Deriaud E, Jiao X, Braun D, Leclerc C, Lo-Man R. Type I
interferons protect neonates from acute inflammation through interleukin
10-producing B cells. J Exp Med 2007; 204 :1107-18.
53. de la Varga-Martínez R, Rodríguez-Bayona B, Campos-Caro A, Añez GA,
Medina-Varo F, Rodríguez C. Autoreactive B-lymphocytes in SLE and RA
patients: isolation and characterisation using extractable nuclear and
citrullinated antigens bound to immunobeads. Eur J Immunol 2019;49 :1107-16.
54 . Jackson SW, Davidson A. J BAFF inhibition in SLE—is tolerance
restored? Immunol Rev 2019; 292 :102-19.
55. Mihaylova N, Chipinski P, Bradyanova S, Velikova T, Ivanova-Todorova
E, Chausheva S, Herbáth M, Kalinova D, Prechl J, Kyurkchiev D,
Tchorbanov AI. Suppression of autoreactive T and B lymphocytes by
anti-annexin A1 antibody in a humanized NSG murine model of systemic
lupus erythematosus. Clin Exp Immunol 2020; 199 :278-93.
56. Monroe JG, Bannish G, Fuentes-Panana EM, King LB, Sandel PC, Chung
J, Sater R. Positive and negative selection during B lymphocyte
development. Immunol Res 2003; 27 :427-42.
57. Xu X, Deobagkar-Lele M, Bull, KR, Crockford TL, Mead AJ, Cribbs AP,
Sims D, Anzilotti C, Cornall RJ. An ontogenetic switch drives the
positive and negative selection of B cells. Proc Nat Acad Sci2020; 117 :3718-27.
58. Benhamou D, Labi V, Novak R, Dai I, Shafir-Alon S, Weiss A, Gaujoux
R, Arnold R, Shen-Orr SS, Rajewsky K, Melamed D. A c-Myc/miR17-92/Pten
axis controls PI3K-mediated positive and negative selection in B cell
development and reconstitutes CD19 deficiency. Cell Rep 2016;16 :419-31.
59. Akagi T, Yoshino T, Kondo E. The Fas antigen and Fas-mediated
apoptosis in B-Cell differentiation. Leuk Lymphoma 1998;28 :483-89.
60. Hancz A, Koncz G, Szili D, Sármay G. TLR9-mediated signals rescue
B-cells from Fas-induced apoptosis via inactivation of caspases.Immunol Lett 2012; 143 :77-84.
61. Akiyama C, Tsumiyama K, Uchimura C, Honda E, Miyazaki Y, Sakurai K,
Miura Y, Hashiramoto A, Felsher DW, Shiozawa S. Conditional upregulation
of IFN-α alone is sufficient to induce systemic lupus erythematosus.J Immunol 2019; 203 :835-43.
62. Giordani L, Sanchez M, Libri I, Quaranta MG, Mattioli B, Viora M.
IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig
production. J Leukocyte Biol 2009; 86 :261.
63. Zheng N, Wang B, Fan J, Luo N, Kong Q, Ye H, Zhang J, Ming H, Yu X.
Increased abundance of plasmacytoid dendritic cells and interferon-alpha
induces plasma cell differentiation in patients of IgA nephropathy.Mediators Inflammation 2017; 2017 :1-15.
64. Jiang J, Zhao M, Chang C, Wu H, Lu Q. Type I interferons in the
pathogenesis and treatment of autoimmune diseases. Clin Rev Allerg
Immunol 2020; 59 (2):248-72.
65. Zeng J, Meng X, Zhou P, Yin Z, Xie Q, Zou H, Shen N, Ye Z, Tang Y.
Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone
mice. Arthritis Res Ther 2019; 21 :205.
66. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of
dendritic cell differentiation by IFN-α in systemic lupus erythematosus.Science 2001; 294 :1540-3.
67. Hron JD, Peng SL. Type I IFN protects against murine lupus. J
Immunol 2004; 173 : 2134-42.
68. Wu Y, He S, Bai B, Zhang L, Xue L, Lin Z, Yang X, Zhu F, He P, Tang
W, Zuo J. Therapeutic effects of the artemisinin analog SM934 on
lupus-prone MRL/ lpr mice via inhibition of TLR-triggered B-cell
activation and plasma cell formation. Cell Mol Immunol 2016;13 :379-90.
69. Nguyen KB, Cousens LP, Doughty LA, Pien GC, Durbin JE, Biron CA.
Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1
resolves a paradox. Nat Immunol 2000; 1 :70-6.
70. McKenna K, Beignon AS, Bhardwaj N. Plasmacytoid dendritic cells:
linking innate and adaptive immunity. J Virol 2005;79 :17–27.
71. Shirai A, Conover J, Klinman DM. Increased activation and altered
ratio of IFNg: IL-4 secreting cells in MRL/lpr mice. Autoimmunity1996; 21 :107-16.
72. Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T,
Izui S. Imbalance towards Th1 predominance is associated with
acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin
Invest 1996; 97 :1597-604.
73. Wang RX, Yu CR, Dambuza IM, Mahdi RM, Dolinska MB, Sergeev YV,
Wingfield PT, Kim SH, Egwuagu CE. Interleukin-35 induces regulatory B
cells that suppress autoimmune disease. Nat Med 2014;20 :633-41.
74. Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A
regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T
Cell-dependent inflammatory responses. Immunity 2008;28 :639-50.
75. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The
development and function of regulatory B cells expressing IL-10 (B10
cells) requires antigen receptor diversity and TLR signals. J
Immunol 2009; 182 :7459-72.
76. Rosser EC, Blair PA, Mauri C. Cellular targets of regulatory B
cell-mediated suppression. Molecular Immunol 2014;62 :296-304.
77. Gray M, Miles K, Salter D, Gray D, Savill J. Apoptotic cells protect
mice from autoimmune inflammation by the induction of regulatory B
cells. PNAS 2007; 104 :14080-85.
78. Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings
DJ, Ehrenstein MR, Mauri C. Novel suppressive function of transitional 2
B cells in experimental arthritis. J Immunol 2007;178 :7868-78.
79. Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K,
Sato S, Tedder TF, Fujimoto M. Regulatory B cells (B10 cells) have a
suppressive role in murine lupus: CD19 and B10 Cell deficiency
exacerbates systemic autoimmunity. J Immunol 2010;184 :4801-9.
80. Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA,
Ehrenstein MR, Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit
regulatory capacity in healthy individuals but are functionally impaired
in systemic lupus erythematosus patients. Immunity 2010;32 :129-40.
81. Veglia F, Perego M, Gabrilovich D. Myeloid-derived suppressor cells
coming of age. Nat Immunol 2018; 19 :108.
82. Iwata Y, Furuichi K, Kitagawa K, Hara A, Okumura T, Kokubo S,
Shimizu K, Sakai N, Sagara A, Kurokawa Y, Ueha S, Matsushima K, Kaneko
S, Wada T. Involvement of CD11b+ GR-1low cells in autoimmune disorder in
MRL-Fas lpr mouse. Clin Exp Nephrol 2010; 14 :411-7.
83. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K,
Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito
Y. Myeloid-derived suppressor cells play crucial roles in the regulation
of mouse collagen-induced arthritis. J Immunol 2013;191 :1073-81.
84. Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis
A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P. Crucial
role of granulocytic myeloid-derived suppressor cells in the regulation
of central nervous system autoimmune disease. J Immunol 2012;188 :1136.
85. Xia S, Sha H, Yang L, Ji Y, Ostrand-Rosenberg S, Qi L. Gr-1+ CD11b+
Myeloid-derived suppressor cells suppress inflammation and promote
insulin sensitivity in obesity. J Biol Chem 2011;286 :23591.
86. Makarenkova VP, Bansal V, Matta BM, Perez LA, Ochoa JB. CD11b+/Gr-1+
Myeloid suppressor cells cause T cell dysfunction after traumatic
stress. J Immunol 2006; 176 :2085-94.
87. Park MJ, Lee SH, Kim EK, Lee EJ, Park SH, Kwok SK, Cho ML.
Myeloid-derived suppressor cells induce the expansion of regulatory B
Cells and ameliorate autoimmunity in the sanroque mouse model of
systemic lupus erythematosus. Arthritis Rheumatol 2016;68 :2717-27.
88. Li D, Shi G, Wang J, Zhang D, Pan Y, Dou H, Hou Y. Baicalein
ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in
myeloid-derived suppressor cells. Arthritis Res Ther 2019;21 :105.
89. Bayik D, Tross D, Klinman DM. Factors influencing the
differentiation of human monocytic myeloid-derived suppressor cells into
inflammatory macrophages. Front Immunol 2018; 9 :608.
90. Zhan X, Fang Y, Hu S, Wu Y, Yang K, Liao C, Zhang Y, Huang X, Wu M.
IFN-gamma differentially regulates subsets of Gr-1(+)CD11b(+) myeloid
cells in chronic inflammation. Mol Immunol 2015;66 :451-62.
91. Lian F, Wang Y, Chen J, Xu H, Yang X, Liang L, Zhan Z, Ye Y, Chen M.
Activation of farnesoid X receptor attenuates liver injury in systemic
lupus erythematosus. Rheumatol Int 2012; 32 :1705-10.
92. Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Zhou H,
Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I,
Matsushima K, Kaneko S, Wada T. Dendritic cells contribute to autoimmune
kidney injury in MRL-Faslpr mice. J Rheumatol 2009;36 :306-14.
93. Yui MA, Brissette WH, Brennan DC, Wuthrich RP, Rubin-Kelley VE.
Increased macrophage colony-stimulating factor in neonatal and adult
autoimmune MRL-lpr mice. Am J Pathol 1991; 139 :255-61.
94. Bird AK, Chang M, Barnard J, Goldman BI, Meednu N, Rangel-Moreno J,
Anolik JH. Neutrophils slow disease progression in murine lupus via
modulation of autoreactive germinal centers. J Immunol 2017;199 :458-466.
95. Vlachou K, Mintzas K, Glymenaki M, Ioannou M, Papadaki G, Bertsias
GK, Sidiropoulos P, Boumpas DT, Verginis P. Elimination of granulocytic
myeloid-derived suppressor cells in lupus-prone mice due to reactive
oxygen species-dependent extracellular trap formation. Arthritis
Rheumatol 2016; 68 :449-61.