Prevalence of TC in ABCG2 variant carriers Prevalence of TC in ABCG2 wt controls Effect of TC UGT1A9 c.98 genotype (ROM or GMR) Bias-corrected effect of ABCG2 c.421 variant allele
GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40 GMR that needs to be adjusted for bias =1.40
6% 2% 1.10 1.40
5% 1% 1.10 1.40
10% 2% 1.10 1.39
6% 2% 1.50 1.37
5% 1% 1.50 1.37
10% 2% 1.50 1.35
GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31 GMR that needs to be adjusted for bias =1.31
6% 2% 1.10 1.31
5% 1% 1.10 1.31
10% 2% 1.10 1.30
6% 2% 1.50 1.29
5% 1% 1.50 1.28
10% 2% 1.50 1.26