|
Variant |
|
Wt |
|
d |
Variant |
|
Wt |
|
d |
N |
12 |
|
56 |
|
— |
11 |
|
43 |
|
— |
MMF |
2 (16.7) |
|
21 (37.5) |
|
-0.715 |
3.3 (29.6) |
|
12.9 (30.1) |
|
-0.009 |
EC-MPS |
10 (83.3) |
|
35 (62.5) |
|
0.715 |
7.7 (70.4) |
|
30.1
(69.9) |
|
0.009 |
Cyclosporine |
6 (50.0) |
|
37 (66.1) |
|
-0.715 |
7.5 (68.5) |
|
29.5 (68.5) |
|
0.000 |
Tacrolimus |
6 (50.0) |
|
19 (33.9) |
|
0.715 |
3.5 (31.5) |
|
13.5
(31.5) |
|
0.000 |
SLCO1B1 variant |
4 (33.3) |
|
21 (37.5) |
|
-0.087 |
4.3
(38.9) |
|
15.4 (35.8) |
|
0.062 |
SLCO1B1 wild type |
8 (66.7) |
|
35 (62.5) |
|
0.087 |
6.7
(61.1) |
|
27.6 (64.2) |
|
-0.062 |
ABCC2 -24 variant |
2 (16.7) |
|
19 (33.9) |
|
-0.405 |
2.0
(18.5) |
|
8.0 (18.5) |
|
0.000 |
ABCC2 -24 wild type |
10 (83.3) |
|
37 (66.1) |
|
0.405 |
9.0
(81.5) |
|
35.0 (81.5) |
|
0.000 |
ABCC2 1249 variant |
4 (33.3) |
|
23 (41.1) |
|
-0.161 |
4.7
(42.6) |
|
18.3 (42.6) |
|
0.000 |
ABCC2 1249 wild type |
8 (66.7) |
|
33 (58.9) |
|
0.161 |
6.3
(57.4) |
|
24.7 (57.4) |
|
0.000 |
UGT2B7 variant |
9 (75.0) |
|
47 (83.9) |
|
-0.222 |
9.6
(87.0) |
|
37.4 (87.0) |
|
0.000 |
UGT2B7 wild type |
3 (25.0) |
|
9 (16.1) |
|
0.222 |
1.4
(13.0) |
|
5.6 (13.0) |
|
0.000 |
UGT1A9 variant diplotype |
0 |
|
3 (5.4) |
|
-0.336 |
0 |
|
0 |
|
0.000 |
UGT1A9 wild type diplotype |
12 (100) |
|
53 (94.6) |
|
0.336 |
11 (100) |
|
43 (100) |
|
0.000 |
ABCB1 wild type/ 1 var allele |
3 (25.0) |
|
15 (26.8) |
|
-0.041 |
3.9 (35.2) |
|
14.4 (33.5) |
|
0.035 |
ABCB1 2 -3 variant alleles |
6 (50.0) |
|
25 (44.6) |
|
0.108 |
4.1 (37.0) |
|
17.4 (40.5) |
|
-0.071 |
ABCB1 4 -6 variant alleles |
3 (25.0) |
|
16 (28.6) |
|
-0.081 |
3.1 (27.8) |
|
11.2 (26.0) |
|
0.039 |
Donors’ ABCC2 1249 variant |
6 (50.0) |
|
21 (37.5) |
|
0.282 |
7.7 (70.4) |
|
18.7 (43.5) |
|
0.564 |
Donors’ ABCC2 1249 wild type |
6 (50.0) |
|
35 (62.5) |
|
-0.282 |
3.3 (29.6) |
|
24.4 (56.5) |
|
-0.564 |
Age (years) |
46.5±13.3 |
|
50.0±12.8 |
|
-0.301 |
50.9±11.7 |
|
50.7±13.1 |
|
0.014 |
BMI (kg/m2) |
24.9±6.3 |
|
24.0±3.3 |
|
0.182 |
23.5±5.6 |
|
24.1±3.3 |
|
-0.121 |
eCrCl (mL/min) |
45±16 |
|
41±11 |
|
0.315 |
44.3±13.2 |
|
41.4±11.1 |
|
0.234 |
Rescaled ln(CNI trough) (µg/L)1
|
5.34±0.21 |
|
5.26±0.37 |
|
0.230 |
5.33±0.20 |
|
5.31±0.38 |
|
0.057 |
PK outcomes |
|
|
|
|
|
|
|
|
|
|
AUCτ,ss (mg•hr/L) |
73.2 (57.3) |
|
50.3 (44.8) |
|
0.775 |
67.8 (41.8) |
|
48.9 (40.9) |
|
0.824 |
Cmax,ss (mg/L) |
16.1 (64.9) |
|
15.9 (60.5) |
|
0.023 |
15.3 (50.2) |
|
14.7 (64.4) |
|
0.072 |
C0 (mg/L) |
4.6 (91.0) |
|
2.8 (101) |
|
0.625 |
3.5
(91.0) |
|
2.7 (101) |
|
0.307 |
C12 (mg/L) |
2.8 (149) |
|
1.8 (101) |
|
0.456 |
2.2
(143) |
|
1.8 (106) |
|
0.212 |
CLT/F,ss (mL/min/kg) |
2.2 (77.0) |
|
3.3 (48.0) |
|
-0.715 |
2.7 (61.2) |
|
3.4 (42.7) |
|
-0.515 |
Cmax/AUCτ (1/hr) |
0.22 (51.0) |
|
0.32 (56.0) |
|
-0.715 |
0.22 (49.5) |
|
0.30 (60.8) |
|
-0.559 |