Before matching Before matching Before matching Before matching Before matching After matching After matching After matching After matching After matching
Variant Wt d Variant Wt d
N 12 56 11 43
MMF 2 (16.7) 21 (37.5) -0.715 3.3 (29.6) 12.9 (30.1) -0.009
EC-MPS 10 (83.3) 35 (62.5) 0.715 7.7 (70.4) 30.1 (69.9) 0.009
Cyclosporine 6 (50.0) 37 (66.1) -0.715 7.5 (68.5) 29.5 (68.5) 0.000
Tacrolimus 6 (50.0) 19 (33.9) 0.715 3.5 (31.5) 13.5 (31.5) 0.000
SLCO1B1 variant 4 (33.3) 21 (37.5) -0.087 4.3 (38.9) 15.4 (35.8) 0.062
SLCO1B1 wild type 8 (66.7) 35 (62.5) 0.087 6.7 (61.1) 27.6 (64.2) -0.062
ABCC2 -24 variant 2 (16.7) 19 (33.9) -0.405 2.0 (18.5) 8.0 (18.5) 0.000
ABCC2 -24 wild type 10 (83.3) 37 (66.1) 0.405 9.0 (81.5) 35.0 (81.5) 0.000
ABCC2 1249 variant 4 (33.3) 23 (41.1) -0.161 4.7 (42.6) 18.3 (42.6) 0.000
ABCC2 1249 wild type 8 (66.7) 33 (58.9) 0.161 6.3 (57.4) 24.7 (57.4) 0.000
UGT2B7 variant 9 (75.0) 47 (83.9) -0.222 9.6 (87.0) 37.4 (87.0) 0.000
UGT2B7 wild type 3 (25.0) 9 (16.1) 0.222 1.4 (13.0) 5.6 (13.0) 0.000
UGT1A9 variant diplotype 0 3 (5.4) -0.336 0 0 0.000
UGT1A9 wild type diplotype 12 (100) 53 (94.6) 0.336 11 (100) 43 (100) 0.000
ABCB1 wild type/ 1 var allele 3 (25.0) 15 (26.8) -0.041 3.9 (35.2) 14.4 (33.5) 0.035
ABCB1 2 -3 variant alleles 6 (50.0) 25 (44.6) 0.108 4.1 (37.0) 17.4 (40.5) -0.071
ABCB1 4 -6 variant alleles 3 (25.0) 16 (28.6) -0.081 3.1 (27.8) 11.2 (26.0) 0.039
Donors’ ABCC2 1249 variant 6 (50.0) 21 (37.5) 0.282 7.7 (70.4) 18.7 (43.5) 0.564
Donors’ ABCC2 1249 wild type 6 (50.0) 35 (62.5) -0.282 3.3 (29.6) 24.4 (56.5) -0.564
Age (years) 46.5±13.3 50.0±12.8 -0.301 50.9±11.7 50.7±13.1 0.014
BMI (kg/m2) 24.9±6.3 24.0±3.3 0.182 23.5±5.6 24.1±3.3 -0.121
eCrCl (mL/min) 45±16 41±11 0.315 44.3±13.2 41.4±11.1 0.234
Rescaled ln(CNI trough) (µg/L)1 5.34±0.21 5.26±0.37 0.230 5.33±0.20 5.31±0.38 0.057
PK outcomes
AUCτ,ss (mg•hr/L) 73.2 (57.3) 50.3 (44.8) 0.775 67.8 (41.8) 48.9 (40.9) 0.824
Cmax,ss (mg/L) 16.1 (64.9) 15.9 (60.5) 0.023 15.3 (50.2) 14.7 (64.4) 0.072
C0 (mg/L) 4.6 (91.0) 2.8 (101) 0.625 3.5 (91.0) 2.7 (101) 0.307
C12 (mg/L) 2.8 (149) 1.8 (101) 0.456 2.2 (143) 1.8 (106) 0.212
CLT/F,ss (mL/min/kg) 2.2 (77.0) 3.3 (48.0) -0.715 2.7 (61.2) 3.4 (42.7) -0.515
Cmax/AUCτ (1/hr) 0.22 (51.0) 0.32 (56.0) -0.715 0.22 (49.5) 0.30 (60.8) -0.559