Pharmacokinetic indicators
Standard MPA steady-state measures [peak exposure
(Cmax,ss mg/L), area under the concentration-time curve
over the dosing interval of 12 hours (AUCτ,ss mg × h/L),
morning and evening pre-dose concentrations (C0,
C12, mg/L), apparent total body clearance
(CLT/F,ss mL/min/kg)] were determined by the
non-compartmental method (Kinetica 4.1, InnaPhase Corp., USA). We
calculated also the Cmax/AUCτ,ss (1/h)
ratio as an indicator of the absorption rate [20]. The analysis was
based on dose-normalized concentrations (per 1000 mg) accounting for the
fact that 1000 mg of MMF corresponded to 739 mg of MPA and 1000 mg of
EC-MPS corresponded to 936 mg of MPA.