Legends to figures:
Figure 1: Prisma flow chart
Figure 2: Composite of kidney failure; A= Kidney failure, B= End-stage kidney disease, C= Sustained decrease to 15 ml/min/1.73 m2, D= Sustained decrease of eGFR by > 40% from baseline, E= Death from renal causes, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 3: Composite Cardiovascular outcomes; A= Cardiovascular-related mortality, B= Hospitalization for heart failure, C= Non-fatal MI, D= non-fatal stroke, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 4: Secondary outcomes; A= Mortality due to any cause, B= Hospitalization for any cause, C= Sustained decrease of >/= 57% in eGFR from baseline, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 5: Adverse events; A= Total number of patients experiencing adverse events, B= Adverse events related to the treatment regimen, C= Adverse events leading to discontinuation of treatment, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 6: Serious adverse events: A= Total number of patients experiencing serious adverse events, B= Adverse events related to the trial regimen, C= Adverse events leading to discontinuation of trial, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 7: Hyperkalemia: A= Investigator reported hyperkalemia, B=Hyperkalemia related to the trial regimen, C= Permanent discontinuation of trial regimen due to hyperkalemia, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 8: Serious Hyperkalemia: A=Total number of patients with serious hyperkalemia, B= Hospitalization due to hyperkalemia, RR= Relative risk, CI= confidence interval, I2= heterogeneity.
Figure 9: Hypokalemia, RR= Relative risk, CI= confidence interval, I2= heterogeneity
Figure 10: Renal related adverse events: A= Acute kidney injury, B= Hospitalization due to acute kidney injury, discontinuation of trial regimen due to acute kidney injury, C= Discontinuation of treatment regimen due to acute kidney injury, D = Hospitalization due to acute renal failure, RR= Relative risk, CI= confidence interval, I2= heterogeneity