Notes : SEEDi1.0-3.0 technologies were developed based on core healthy elements; that is, sleep-emotion-exercise-diet (SEED) intervention (SEEDi). When E(e)SEED-BasED healthy lifestyle included external and internal environment combines with RT-ABCDEF and Grade 210 prevention, it’s 3.0 version of SEEDi (SEEDi3.0) or General Formula (Health & Longevity equality) for major non-communicable diseases (mNCDs). GLPR agonists: glucagon-like peptide-1 receptor agonists; SGLT2 inhibitors: sodium-glucose cotransporter 2 inhibitors.