iRT-ABCDEFG Tips
G Goals are less MACCE and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life.
F Follow-up with registered subjects or patients, especially populations with family history, IGT, and an unhealthy lifestyle for primary and secondary prevention, tracking outcome and evaluating effects of intensive medical therapy (oral drugs or insulin injection) and surgery. It’s very important for a population-based study.
E Examination for early diagnosis, treatment, and prevention, which includes large-scale screening and regular comprehensive or targeted physical examinations, such as biomarkers (fasting blood-glucose, postprandial blood glucose, hemoglobin Alc, and others: FGF21, lipoprotein(a), microalbuminuria, RAGE, salusin-α and salusin-β), oral glucose tolerance test, ß cell function, genetic variants (e.g. nitric oxide synthase 1 adaptor protein, FOXO1 gene), ultrasonography, histopathological analysis, coronary angiography, CT angiography & MRI. Risk stratification following these examinations and related scoring will improve treatment and clinical outcomes.
D Diseases and risk factor control, which includes prediabetes state or impaired glucose tolerance, hypertension, dyslipidemia, chronic infection, and diabetic complications (e.g. retinopathy or chronic kidney disease, hypoglycemia, peripheral neuropathy, diabetic ketoacidosis and other CVDs), obesity, physical inactivity, and heavy drinking or smoking.
C Change unhealthy E(e)SEEDi lifestyle with SEEDi1.0-3.0 technologies, such as not staying up late, being physically active, no smoking and drinking; Chinese medicine is a good choice; Controlling the source of infection and the spread of pathways  during the pandemic are vital strategies if accompanied by acute infectious diseases (e.g. COVID-19); And Cutting off the genetic pathways by RNAi, gene knockout or CRISP/Cas9 gene editing after an ethical approval and patients consent due to a genetic predisposition to diabetes.
B Biohazard control, which includes abnormal symptoms and physiological indexes, HbA1c level of bio-markers, family history, intensive weight management for obesity, and control of diabetic complications. Monitoring or self-monitoring of blood glucose levels is important and necessary.
A Antagonistic treatment, which includes oral hypoglycemic agents (such as GLPR agonists, SGLT2 inhibitors), insulin monotherapy, statin-based treatment, bariatric surgery, guidelines and other related methods.
iRT intervention with these strategies as Routine, Right & Reversible Treatment.