Secondary outcomes
The CGM parameters between the unblinded and blinded groups across the
three trimesters of pregnancy that represent glycaemic control (%TIR,
%TAR and %TBR) are presented in Figure 2, and parameters including
mean glucose and glycaemic variability (SD, MAGE and %CV) are presented
in Figure S2. There were trends of higher %TIR in the first trimester
[83.2% (74.1- 93.9) vs 78.1% (58.9-87.1); p=0.06], and third
trimester [90.2% (77.9-95.8) vs 79.5% (65.1-90.4); p=0.07],
compared to the blinded group users. Significant associations were only
seen in the early second trimester of pregnancy at 8-13 weeks [88.7%
(76.4-92.7) vs 80.5% (59.6-90.4), p=0.02]. Conversely, there was a
trend of lower %TBR in the first trimester [15.4 (4.09- 24.9) vs 21.2
(11.3-38.5); p=0.06], and the early second trimester [8.8 (5.4-20.9)
vs 16.9 (6.4-34.2); p=0.05] (Figure S2 and Table S2). There were no
significant differences between the unblinded and blinded groups for
%TAR, mean, SD, MAGE and %CV levels (Figure S2).