Limitations
First, this study had the typical limitation of a retrospective study.
The indication of TAVR for bicuspid aortic valve instead of SAVR, the
choice of THV type or size may differ among the centers. Second, there
have been published two different methods of measuring MS, and the gold
standard was still controversial. The results that MS was not
significantly different between the 2 groups might be different when the
other way is employed. Third, as to clinical outcomes other than CD, the
results should be interpreted with care, since the study cohort excluded
the patients who potentially develop complications. Two implantation
failures and no intraprocedural death were excluded from the BAV cohort,
and 2 implantation failures 2 intraprocedural death were excluded from
TAV group. Fourth, PS matching was modeled with the TAV cohort from
single-center, while the BAV cohort consisted of the patients from 3
centers. Also, even though the PS matching has balanced patient
characteristics, several factors were not included in the model and
unmeasured confound factors may not be eliminated.