Methods
For this retrospective case series review, the requirement for patient
informed consent was waived by the Boston Children’s Hospital
Institutional Review Board.
Diagnostic CT and MRI examinations were performed using standard
techniques; MRI was performed at 3T.
PET/CT exams were performed using a Siemens Biograph mCT Flow PET/CT
scanner equipped with 64 slice CT. Low dose attenuation correction CT
images utilized CARE kV dose reduction and CARE Dose 4D tube current
modulation. PET images were acquired in 3D mode with dead time
correction, decay correction, scatter correction, and time of flight and
reconstructed with standard iterative reconstruction parameters at 3 mm
increments.
18F-FDG: 5.55 MBq/kg (0.15 mCi/kg, 10 mCi maximum) was
administered 60 min prior to imaging.
68Ga-DOTATATE: 2.74 MBq/kg (0.074 mCi/kg; 5.4 mCi
maximum) was administered 60 min prior to imaging.
123I-MIBG scintigraphy was performed using a Siemens
Intevo SPECT/CT equipped with medium energy collimators and 16 slice CT.
Low dose attenuation correction SPECT/CT images were acquired at 80-100
kVp using CARE Dose 4D tube current modulation. SPECT images were
acquired in continuous non-circular mode with 2x360° camera head
rotations at 15sec per stop equivalent and reconstructed with FLASH 3D
iterative reconstruction per manufacturer recommendations. Static planar
images were acquired in anterior/posterior and lateral projections.
123I-MIBG: 5.18 MBq/kg (0.14 mCi/kg, 10 mCi maximum)
was administered 24hrs prior to imaging.