Methods
For this retrospective case series review, the requirement for patient informed consent was waived by the Boston Children’s Hospital Institutional Review Board.
Diagnostic CT and MRI examinations were performed using standard techniques; MRI was performed at 3T.
PET/CT exams were performed using a Siemens Biograph mCT Flow PET/CT scanner equipped with 64 slice CT. Low dose attenuation correction CT images utilized CARE kV dose reduction and CARE Dose 4D tube current modulation. PET images were acquired in 3D mode with dead time correction, decay correction, scatter correction, and time of flight and reconstructed with standard iterative reconstruction parameters at 3 mm increments.
18F-FDG: 5.55 MBq/kg (0.15 mCi/kg, 10 mCi maximum) was administered 60 min prior to imaging.
68Ga-DOTATATE: 2.74 MBq/kg (0.074 mCi/kg; 5.4 mCi maximum) was administered 60 min prior to imaging.
123I-MIBG scintigraphy was performed using a Siemens Intevo SPECT/CT equipped with medium energy collimators and 16 slice CT. Low dose attenuation correction SPECT/CT images were acquired at 80-100 kVp using CARE Dose 4D tube current modulation. SPECT images were acquired in continuous non-circular mode with 2x360° camera head rotations at 15sec per stop equivalent and reconstructed with FLASH 3D iterative reconstruction per manufacturer recommendations. Static planar images were acquired in anterior/posterior and lateral projections.
123I-MIBG: 5.18 MBq/kg (0.14 mCi/kg, 10 mCi maximum) was administered 24hrs prior to imaging.