Introduction
In 2019 the novel coronavirus started a pandemic and ever since millions have been affected in the respiratory system and other organs like the skin. Ever since the first vaccines got authorized for use, many people have become immune to severe forms of infection and many lives have been saved [1]. However, complications and side effects of the vaccines were also reported [2]. Even though cutaneous reaction to vaccines is not a novel concept and many reactions are known to have happened, some reactions are more severe and require intensive care. COVID-19 Vaccine-induced TEN is a rare incidence on its own and only a few cases have been reported [3].
Toxic epidermal necrolysis is an idiosyncratic drug reaction that is associated with high mortality and morbidity rates [4 5]. This spectrum of diseases is heralded by an acute fever which is followed by a generalized dusky rash, crusting, extensive erosion, conjunctivitis, necrolysis of the epidermis, mucositis, In both the pulmonary and gastrointestinal tract [5] [6]. It is estimated that the mortality of TEN is around 30%. Several drugs such as sulfonamides, anti-convulsive medications, and even influenza vaccines are known to be chiefly associated with this reaction; however, vaccines are among the least associated causes [5] [7].
In this article, we report a case of TEN following the administration of the Sinopharm COVID-19 vaccine. TEN is an important entity even though it has rarely been reported with COVID-19 vaccines. The current report will also provide a brief review of the literature concerning the reported TEN/SJS cases that are induced by a COVID-19 vaccine.