Figure 1. Schematic of the mutational events around theCyp6aa/Cyp6p cluster on chromosome 2R in Anopheles gambiae . Upper panel shows the three mutational events observed in East and Central African samples. Orange indicates the genes/ transposable elements involved and the blue band the extent of theCyp6aap-Dup1 CNV. The lower panel, redrawn from [20], shows the genomic extent and geographic distribution of the CNVs that have been observed around the Cyp6aa/Cyp6p cluster, 13 out of 15 include Cyp6aa1 .The dark blue shading on the map indicates the geographic extent of Cyp6aap-Dup 1. Data from Uganda, Kenya and DRC are reported extensively in the main text, in addition 27.4% (n=84)of Anopheles gambiae females sampled from northern Tanzania in 2018 were triple mutant carriers.