Table S5: Pretreatment excision compared to No pretreatment
excision for Rhabdomyosarcoma |
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Patient or population: Rhabdomyosarcoma
Intervention: Pretreatment excision
Comparison: No pretreatment excision
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with No pretreatment excision |
Risk
difference with Pretreatment excision |
Mortality |
259
(2 non-randomized
studies)29,30
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⨁○○○
Very lowa,b
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OR 0.41
(0.11 to 1.47)
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753
per 1,000 |
198 fewer per
1,000
(502 fewer to 65 more)
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Mortality - Paratesticular |
32
(1
non-randomized study)29
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⨁○○○
Very lowa
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OR 1.89
(0.08 to 43.52)
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1,000 per 1,000 |
0 fewer per
1,000
(0 fewer to 0 fewer)
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Mortality - Extremity or trunk |
227
(1
non-randomized study)30
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⨁○○○
Very lowb
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OR 0.31
(0.11 to 0.92)
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742
per 1,000 |
271 fewer per
1,000
(502 fewer to 16 fewer)
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Relapse |
25
(1 non-randomized
study)28
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⨁○○○
Very
lowa,b
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OR
1.33
(0.10 to 17.55)
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111 per 1,000 |
31 more per 1,000
(99 fewer to
576 more)
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Relapse - Mixed |
25
(1 non-randomized
study)28
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⨁○○○
Very
lowa,b
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OR
1.33
(0.10 to 17.55)
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111 per 1,000 |
31 more per 1,000
(99 fewer to
576 more)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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