Table S9: Resection at time of emergency presentation compared
to biopsy or diversion for rhabdomyosarcoma |
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Patient or population: Rhabdomyosarcoma
Intervention: Resection at time of emergency presentation
Comparison: Biopsy or diversion
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with biopsy or diversion |
Risk difference
with resection at time of emergency presentation |
Mortality |
394
(1 non-randomized
study)65
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⨁○○○
Very
lowa
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OR
0.79
(0.45 to 1.41)
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684 per 1,000 |
53 fewer per 1,000
(191 fewer
to 69 more)
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Failure free mortality |
458
(2
non-randomized studies)64,65
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⨁○○○
Very lowa,b
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OR 0.77
(0.22 to 2.66)
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663
per 1,000 |
61 fewer per
1,000
(361 fewer to 177 more)
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Failure free mortality - Retroperitoneum/pelvis |
64
(1 non-randomized
study)64
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⨁○○○
Very
lowa
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OR
0.37
(0.13 to 1.08)
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487 per 1,000 |
227 fewer per 1,000
(377 fewer
to 19 more)
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Failure free mortality - Mixed population |
394
(1 non-randomized
study)65
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⨁○○○
Very
lowa
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OR
1.33
(0.78 to 2.27)
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684 per 1,000 |
58 more per 1,000
(56 fewer to
147 more)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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