Table S7: Late resection compared to No late resection for Rhabdomyosarcoma
Patient or population: Rhabdomyosarcoma Intervention: Late resection Comparison: No late resection
Outcomes № of participants
(studies)
Follow-up Certainty of the evidence
(GRADE) Relative effect
(95% CI) Anticipated absolute effects
Risk with No late resection Risk difference with Late resection
Mortality 758 (5 non-randomized studies)41-45 ⨁○○○ Very lowa,b,c OR 1.47 (0.37 to 5.93) 788 per 1,000 57 more per 1,000 (209 fewer to 169 more)
Mortality – Bladder 28 (1 non-randomized study)43 ⨁○○○ Very lowc OR 3.72 (0.14 to 99.48) Study population
1,000 per 1,000 0 fewer per 1,000 (0 fewer to 0 fewer)
Low
10 per 1,000 26 fewer per 1,000 (9 fewer to 491fewer)
Mortality - Vagina, vulva 19 (1 non-randomized study)41 ⨁○○○ Very lowa,c OR 0.51 (0.02 to 14.28) 917 per 1,000 68 fewer per 1,000 (736 fewer to 77 more)
Mortality - Mixed population 711 (3 non-randomized studies)42,44,45 ⨁○○○ Very lowa,c,d OR 1.71 (0.25 to 11.77) 780 per 1,000 78 more per 1,000 (310 fewer to 196 more)
Relapse 194 (3 non-randomized studies)27,42,43 ⨁○○○ Very lowa,c OR 2.21 (0.98 to 5.01) 125 per 1,000 115 more per 1,000 (2 fewer to 292 more)
Relapse - Bladder 28 (1 non-randomized study)43 ⨁○○○ Very lowc OR 3.72 (0.14 to 99.48) Study population
0 per 1,000 0 fewer per 1,000 (0 fewer to 0 fewer)
Low
10 per 1,000 26 fewer per 1,000 (9 fewer to 491 fewer)
Relapse - Mixed population 166 (2 non-randomized studies)27,42 ⨁○○○ Very lowa,c OR 2.14 (0.92 to 4.98) 140 per 1,000 119 more per 1,000 (10 fewer to 308 more)
Need additional intensive therapy 63 (1 non-randomized study)42 ⨁○○○ Very lowa,c OR 2.10 (0.45 to 9.68) 170 per 1,000 131 more per 1,000 (86 fewer to 495 more)
Non-relapse mortality 63 (1 non-randomized study)42 ⨁○○○ Very lowa,c OR 0.98 (0.04 to 21.95) 38 per 1,000 1 fewer per 1,000 (36 fewer to 425 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.