Table S7: Late resection compared to No late resection for
Rhabdomyosarcoma |
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Patient or population: Rhabdomyosarcoma
Intervention: Late resection
Comparison: No late resection
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with No late resection |
Risk difference
with Late resection |
Mortality |
758
(5 non-randomized
studies)41-45
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⨁○○○
Very lowa,b,c
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OR 1.47
(0.37 to 5.93)
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788
per 1,000 |
57 more per
1,000
(209 fewer to 169 more)
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Mortality – Bladder |
28
(1
non-randomized study)43
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⨁○○○
Very lowc
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OR 3.72
(0.14 to 99.48)
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Study population |
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1,000 per 1,000 |
0 fewer per
1,000
(0 fewer to 0 fewer)
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Low |
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10 per 1,000 |
26 fewer per
1,000
(9 fewer to 491fewer)
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Mortality - Vagina, vulva |
19
(1
non-randomized study)41
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⨁○○○
Very lowa,c
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OR 0.51
(0.02 to 14.28)
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917
per 1,000 |
68 fewer per
1,000
(736 fewer to 77 more)
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Mortality - Mixed population |
711
(3
non-randomized studies)42,44,45
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⨁○○○
Very lowa,c,d
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OR 1.71
(0.25 to 11.77)
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780
per 1,000 |
78 more per
1,000
(310 fewer to 196 more)
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Relapse |
194
(3 non-randomized
studies)27,42,43
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⨁○○○
Very lowa,c
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OR 2.21
(0.98 to 5.01)
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125
per 1,000 |
115 more per
1,000
(2 fewer to 292 more)
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Relapse - Bladder |
28
(1 non-randomized
study)43
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⨁○○○
Very
lowc
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OR
3.72
(0.14 to 99.48)
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Study population |
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0 per 1,000 |
0 fewer per
1,000
(0 fewer to 0 fewer)
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Low |
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10 per 1,000 |
26 fewer per
1,000
(9 fewer to 491 fewer)
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Relapse - Mixed population |
166
(2
non-randomized studies)27,42
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⨁○○○
Very lowa,c
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OR 2.14
(0.92 to 4.98)
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140
per 1,000 |
119 more per
1,000
(10 fewer to 308 more)
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Need additional intensive therapy |
63
(1 non-randomized
study)42
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⨁○○○
Very
lowa,c
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OR
2.10
(0.45 to 9.68)
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170 per 1,000 |
131 more per 1,000
(86 fewer to
495 more)
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Non-relapse mortality |
63
(1
non-randomized study)42
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⨁○○○
Very lowa,c
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OR 0.98
(0.04 to 21.95)
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38
per 1,000 |
1 fewer per
1,000
(36 fewer to 425 more)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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