Topic |
Research (PICO) question |
Loco-regional evaluation |
1- In patients with RMS, does regional lymph
node evaluation, compared to no evaluation, improve local
control? |
Timing of resection |
2- In patients with RMS, does upfront compared to
Delayed Primary Excision (DPE) improve chance of achieving R0
resection? |
Pretreatment re-excision |
3- In patients with incompletely resected
RMS, does pretreatment re-excision compared to no pretreatment
re-excision, improve rate of R0 resection, local control and reduce the
need for more intensive therapy? |
Neoadjuvant radiation therapy |
4- In patients with unresectable RMS,
does preoperative radiation therapy, compared to no preoperative
radiation therapy, improve local control? |
Margin |
5- In patients with RMS, does resection with a margin of 0.5 cm
compared to 2 cm margin improves local control? |
Tumor bed marking |
6- In patients with RMS, does tumor bed marking with
surgical clips compared to no marking, improve radiation therapy
planning and local control? |
Resection at the end of therapy |
7- In patients with RMS, does late
resection after completion of therapy compared to no resection improve
local control? |
Resection of metastatic disease |
8- In patients with RMS, does
Resection of residual metastatic disease after completion of
chemotherapy compared to no resection of residual metastatic disease
improve survival? |
Resection of relapsed disease |
9- In patients with RMS, does Resection
of relapsed disease compared to no resection of relapsed disease improve
survival? |
Resection of locally advanced disease presenting with obstruction versus
biopsy and diversion if indicated. |
10- In patients with RMS, does
Resection of locally advanced disease presenting with obstruction
compared to biopsy and diversion (if indicated) improve
survival? |