Table S4: Delayed primary excision compared to upfront excision
for Rhabdomyosarcoma |
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Patient or population: Rhabdomyosarcoma
Intervention: Delayed primary excision
Comparison: Upfront excision
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with upfront excision |
Risk difference
with delayed primary excision |
Mortality |
59
(3 non-randomized
studies)18,19,22
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⨁○○○
Very lowa,b
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OR 0.82
(0.20 to 3.47)
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781
per 1,000 |
36 fewer per
1,000
(365 fewer to 144 more)
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Mortality - Head and neck |
16
(1
non-randomized study)18
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⨁○○○
Very lowa,b
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OR 0.50
(0.06 to 4.09)
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500
per 1,000 |
167 fewer per
1,000
(443 fewer to 304 more)
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Mortality - Liver-bile duct |
24
(1
non-randomized study)22
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⨁○○○
Very lowa,b
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OR 1.62
(0.14 to 18.58)
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875
per 1,000 |
44 more per
1,000
(380 fewer to 117 more)
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Mortality - Chest wall |
19
(1
non-randomized study)19
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⨁○○○
Very lowa,b
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OR 0.82
(0.03 to 23.34)
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929
per 1,000 |
14 fewer per
1,000
(648 fewer to 68 more)
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Relapse |
143
(3 non-randomized
studies)18,22,27
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⨁○○○
Very lowa,b
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OR 2.08
(0.89 to 4.87)
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163
per 1,000 |
125 more per
1,000
(15 fewer to 324 more)
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Relapse - Head and neck |
16
(1
non-randomized study)18
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⨁○○○
Very lowa,b
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OR 4.00
(0.43 to 37.11)
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200
per 1,000 |
300 more per
1,000
(103 fewer to 703 more)
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Relapse - Liver-bile duct |
24
(1
non-randomized study)22
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⨁○○○
Very lowa,b
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OR 2.33
(0.22 to 25.24)
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125
per 1,000 |
125 more per
1,000
(95 fewer to 658 more)
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Relapse - Mixed population |
103
(1
non-randomized study)27
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⨁○○○
Very lowa,b
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OR 1.79
(0.66 to 4.85)
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162
per 1,000 |
95 more per
1,000
(49 fewer to 322 more)
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Incomplete resection |
287
(6
non-randomized studies)18-23
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⨁○○○
Very lowa
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OR 0.27
(0.15 to 0.51)
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378
per 1,000 |
237 fewer per
1,000
(294 fewer to 141 fewer)
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Incomplete resection - Head and neck |
16
(1 non-randomized
study)18
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⨁○○○
Very
lowa,b
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OR
0.26
(0.01 to 6.44)
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800 per 1,000 |
290 fewer per 1,000
(762 fewer
to 163 more)
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Incomplete resection - Liver-bile duct |
24
(1 non-randomized
study)22
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⨁○○○
Very
lowa,b
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OR
0.05
(0.00 to 0.52)
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125 per 1,000 |
118 fewer per 1,000
(125 fewer
to 56 fewer)
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Incomplete resection - Chest wall |
19
(1 non-randomized
study)19
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⨁○○○
Very
lowa,b
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OR
0.67
(0.08 to 5.30)
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500 per 1,000 |
99 fewer per 1,000
(426 fewer
to 341 more)
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Incomplete resection - Perianal/perineal |
29
(1 non-randomized
study)20
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⨁○○○
Very
lowa,b
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OR
0.36
(0.03 to 3.96)
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77 per 1,000 |
48 fewer per 1,000
(74 fewer to
171 more)
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Incomplete resection - Extremity |
155
(1 non-randomized
study)23
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⨁○○○
Very
lowa
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OR
0.37
(0.17 to 0.79)
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500 per 1,000 |
230 fewer per 1,000
(355 fewer
to 59 fewer)
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Incomplete resection - Mixed population |
44
(1 non-randomized
study)21
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⨁○○○
Very
lowa,b
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OR
0.09
(0.02 to 0.48)
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118 per 1,000 |
106 fewer per 1,000
(115 fewer
to 57 fewer)
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Need for additional intensive therapy |
34
(1 non-randomized
study)22
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⨁○○○
Very
lowa,b
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OR
1.56
(0.39 to 6.25)
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333 per 1,000 |
105 more per 1,000
(170 fewer
to 424 more)
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Need for additional intensive therapy - Liver-bile duct |
34
(1 non-randomized
study)22
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⨁○○○
Very
lowa,b
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OR
1.56
(0.39 to 6.25)
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333 per 1,000 |
105 more per 1,000
(170 fewer
to 424 more)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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