Table S3: Lymph node evaluation compared to no lymph node
evaluation in patients with rhabdomyosarcoma |
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Patient or population: Rhabdomyosarcoma
Intervention: Lymph node evaluation
Comparison: No lymph node evaluation
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with no lymph node evaluation |
Risk
difference with Lymph node evaluation |
Mortality |
1239
(4 non-randomized
studies)5
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⨁○○○
Very lowa,b
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OR 0.46
(0.22 to 0.96)
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849
per 1,000 |
128 fewer per
1,000
(296 fewer to 5 fewer)
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Mortality - Extremities |
537
(1
non-randomized study)5
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⨁⨁○○
Low
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OR 0.32
(0.17 to 0.60)
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769
per 1,000 |
253 fewer per
1,000
(407 fewer to 103 fewer)
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Mortality - Paratesticular |
702
(3
non-randomized studies)1,8
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⨁○○○
Very lowa,b,c
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OR 0.61
(0.20 to 1.88)
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919
per 1,000 |
45 fewer per
1,000
(224 fewer to 36 more)
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Relapse |
234
(1 non-randomized
study)1
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⨁○○○
Very
lowa,c
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RR
0.92
(0.45 to 1.90)
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119 per 1,000 |
10 fewer per 1,000
(66 fewer to
107 more)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio; RR: risk ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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