Table S9: Resection at time of emergency presentation compared to biopsy or diversion for rhabdomyosarcoma
Patient or population: Rhabdomyosarcoma Intervention: Resection at time of emergency presentation Comparison: Biopsy or diversion
Outcomes № of participants
(studies)
Follow-up Certainty of the evidence
(GRADE) Relative effect
(95% CI) Anticipated absolute effects
Risk with biopsy or diversion Risk difference with resection at time of emergency presentation
Mortality 394 (1 non-randomized study)65 ⨁○○○ Very lowa OR 0.79 (0.45 to 1.41) 684 per 1,000 53 fewer per 1,000 (191 fewer to 69 more)
Failure free mortality 458 (2 non-randomized studies)64,65 ⨁○○○ Very lowa,b OR 0.77 (0.22 to 2.66) 663 per 1,000 61 fewer per 1,000 (361 fewer to 177 more)
Failure free mortality - Retroperitoneum/pelvis 64 (1 non-randomized study)64 ⨁○○○ Very lowa OR 0.37 (0.13 to 1.08) 487 per 1,000 227 fewer per 1,000 (377 fewer to 19 more)
Failure free mortality - Mixed population 394 (1 non-randomized study)65 ⨁○○○ Very lowa OR 1.33 (0.78 to 2.27) 684 per 1,000 58 more per 1,000 (56 fewer to 147 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.