Topic Research (PICO) question
Loco-regional evaluation 1- In patients with RMS, does regional lymph node evaluation, compared to no evaluation, improve local control?
Timing of resection 2- In patients with RMS, does upfront compared to Delayed Primary Excision (DPE) improve chance of achieving R0 resection?
Pretreatment re-excision 3- In patients with incompletely resected RMS, does pretreatment re-excision compared to no pretreatment re-excision, improve rate of R0 resection, local control and reduce the need for more intensive therapy?
Neoadjuvant radiation therapy 4- In patients with unresectable RMS, does preoperative radiation therapy, compared to no preoperative radiation therapy, improve local control?
Margin 5- In patients with RMS, does resection with a margin of 0.5 cm compared to 2 cm margin improves local control?
Tumor bed marking 6- In patients with RMS, does tumor bed marking with surgical clips compared to no marking, improve radiation therapy planning and local control?
Resection at the end of therapy 7- In patients with RMS, does late resection after completion of therapy compared to no resection improve local control?
Resection of metastatic disease 8- In patients with RMS, does Resection of residual metastatic disease after completion of chemotherapy compared to no resection of residual metastatic disease improve survival?
Resection of relapsed disease 9- In patients with RMS, does Resection of relapsed disease compared to no resection of relapsed disease improve survival?
Resection of locally advanced disease presenting with obstruction versus biopsy and diversion if indicated. 10- In patients with RMS, does Resection of locally advanced disease presenting with obstruction compared to biopsy and diversion (if indicated) improve survival?