Table S4: Delayed primary excision compared to upfront excision for Rhabdomyosarcoma
Patient or population: Rhabdomyosarcoma Intervention: Delayed primary excision Comparison: Upfront excision
Outcomes № of participants
(studies)
Follow-up Certainty of the evidence
(GRADE) Relative effect
(95% CI) Anticipated absolute effects
Risk with upfront excision Risk difference with delayed primary excision
Mortality 59 (3 non-randomized studies)18,19,22 ⨁○○○ Very lowa,b OR 0.82 (0.20 to 3.47) 781 per 1,000 36 fewer per 1,000 (365 fewer to 144 more)
Mortality - Head and neck 16 (1 non-randomized study)18 ⨁○○○ Very lowa,b OR 0.50 (0.06 to 4.09) 500 per 1,000 167 fewer per 1,000 (443 fewer to 304 more)
Mortality - Liver-bile duct 24 (1 non-randomized study)22 ⨁○○○ Very lowa,b OR 1.62 (0.14 to 18.58) 875 per 1,000 44 more per 1,000 (380 fewer to 117 more)
Mortality - Chest wall 19 (1 non-randomized study)19 ⨁○○○ Very lowa,b OR 0.82 (0.03 to 23.34) 929 per 1,000 14 fewer per 1,000 (648 fewer to 68 more)
Relapse 143 (3 non-randomized studies)18,22,27 ⨁○○○ Very lowa,b OR 2.08 (0.89 to 4.87) 163 per 1,000 125 more per 1,000 (15 fewer to 324 more)
Relapse - Head and neck 16 (1 non-randomized study)18 ⨁○○○ Very lowa,b OR 4.00 (0.43 to 37.11) 200 per 1,000 300 more per 1,000 (103 fewer to 703 more)
Relapse - Liver-bile duct 24 (1 non-randomized study)22 ⨁○○○ Very lowa,b OR 2.33 (0.22 to 25.24) 125 per 1,000 125 more per 1,000 (95 fewer to 658 more)
Relapse - Mixed population 103 (1 non-randomized study)27 ⨁○○○ Very lowa,b OR 1.79 (0.66 to 4.85) 162 per 1,000 95 more per 1,000 (49 fewer to 322 more)
Incomplete resection 287 (6 non-randomized studies)18-23 ⨁○○○ Very lowa OR 0.27 (0.15 to 0.51) 378 per 1,000 237 fewer per 1,000 (294 fewer to 141 fewer)
Incomplete resection - Head and neck 16 (1 non-randomized study)18 ⨁○○○ Very lowa,b OR 0.26 (0.01 to 6.44) 800 per 1,000 290 fewer per 1,000 (762 fewer to 163 more)
Incomplete resection - Liver-bile duct 24 (1 non-randomized study)22 ⨁○○○ Very lowa,b OR 0.05 (0.00 to 0.52) 125 per 1,000 118 fewer per 1,000 (125 fewer to 56 fewer)
Incomplete resection - Chest wall 19 (1 non-randomized study)19 ⨁○○○ Very lowa,b OR 0.67 (0.08 to 5.30) 500 per 1,000 99 fewer per 1,000 (426 fewer to 341 more)
Incomplete resection - Perianal/perineal 29 (1 non-randomized study)20 ⨁○○○ Very lowa,b OR 0.36 (0.03 to 3.96) 77 per 1,000 48 fewer per 1,000 (74 fewer to 171 more)
Incomplete resection - Extremity 155 (1 non-randomized study)23 ⨁○○○ Very lowa OR 0.37 (0.17 to 0.79) 500 per 1,000 230 fewer per 1,000 (355 fewer to 59 fewer)
Incomplete resection - Mixed population 44 (1 non-randomized study)21 ⨁○○○ Very lowa,b OR 0.09 (0.02 to 0.48) 118 per 1,000 106 fewer per 1,000 (115 fewer to 57 fewer)
Need for additional intensive therapy 34 (1 non-randomized study)22 ⨁○○○ Very lowa,b OR 1.56 (0.39 to 6.25) 333 per 1,000 105 more per 1,000 (170 fewer to 424 more)
Need for additional intensive therapy - Liver-bile duct 34 (1 non-randomized study)22 ⨁○○○ Very lowa,b OR 1.56 (0.39 to 6.25) 333 per 1,000 105 more per 1,000 (170 fewer to 424 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.