Table S5: Pretreatment excision compared to No pretreatment excision for Rhabdomyosarcoma
Patient or population: Rhabdomyosarcoma Intervention: Pretreatment excision Comparison: No pretreatment excision
Outcomes № of participants
(studies)
Follow-up Certainty of the evidence
(GRADE) Relative effect
(95% CI) Anticipated absolute effects
Risk with No pretreatment excision Risk difference with Pretreatment excision
Mortality 259 (2 non-randomized studies)29,30 ⨁○○○ Very lowa,b OR 0.41 (0.11 to 1.47) 753 per 1,000 198 fewer per 1,000 (502 fewer to 65 more)
Mortality - Paratesticular 32 (1 non-randomized study)29 ⨁○○○ Very lowa OR 1.89 (0.08 to 43.52) 1,000 per 1,000 0 fewer per 1,000 (0 fewer to 0 fewer)
Mortality - Extremity or trunk 227 (1 non-randomized study)30 ⨁○○○ Very lowb OR 0.31 (0.11 to 0.92) 742 per 1,000 271 fewer per 1,000 (502 fewer to 16 fewer)
Relapse 25 (1 non-randomized study)28 ⨁○○○ Very lowa,b OR 1.33 (0.10 to 17.55) 111 per 1,000 31 more per 1,000 (99 fewer to 576 more)
Relapse - Mixed 25 (1 non-randomized study)28 ⨁○○○ Very lowa,b OR 1.33 (0.10 to 17.55) 111 per 1,000 31 more per 1,000 (99 fewer to 576 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.