Table S6: Preoperative radiation therapy compared to No
preoperative radiation therapy for Rhabdomyosarcoma with unresectabe
tumor |
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Patient or population: Rhabdomyosarcoma with unresectabe tumor
Intervention: Preoperative radiation therapy
Comparison: No preoperative radiation therapy
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Outcomes |
№ of participants |
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(studies) |
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Follow-up |
Certainty of the evidence |
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(GRADE) |
Relative effect |
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(95% CI) |
Anticipated absolute effects |
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Risk with No preoperative radiation therapy |
Risk difference with Preoperative radiation
therapy |
Mortality |
88
(1 non-randomized
study)33
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⨁○○○
Very
lowa,b,c
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OR
0.83
(0.33 to 2.10)
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688 per 1,000 |
41 fewer per 1,000
(267 fewer
to 135 more)
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Mortality or event |
88
(1
non-randomized study)33
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⨁○○○
Very lowa,b,c
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OR 0.92
(0.39 to 2.17)
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604
per 1,000 |
20 fewer per
1,000
(231 fewer to 164 more)
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Relapse |
88
(1 non-randomized
study)33
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⨁○○○
Very
lowa,b,c
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OR
0.71
(0.27 to 1.86)
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292 per 1,000 |
65 fewer per 1,000
(192 fewer
to 142 more)
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Incomplete resection |
88
(1
non-randomized study)33
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⨁○○○
Very lowa,b
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OR 0.02
(0.00 to 0.08)
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250
per 1,000 |
243 fewer per
1,000
(250 fewer to 224 fewer)
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*The risk in the intervention group (and its
95% confidence interval) is based on the assumed risk in the comparison
group and the relative effect of the intervention (and its 95%
CI).
CI: confidence interval; OR: odds
ratio
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GRADE Working Group grades of
evidence
High certainty: we are very confident
that the true effect lies close to that of the estimate of the
effect.
Moderate certainty: we are moderately
confident in the effect estimate: the true effect is likely to be close
to the estimate of the effect, but there is a possibility that it is
substantially different.
Low certainty: our
confidence in the effect estimate is limited: the true effect may be
substantially different from the estimate of the
effect.
Very low certainty: we have very little
confidence in the effect estimate: the true effect is likely to be
substantially different from the estimate of effect.
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