Table S6: Preoperative radiation therapy compared to No preoperative radiation therapy for Rhabdomyosarcoma with unresectabe tumor
Patient or population: Rhabdomyosarcoma with unresectabe tumor Intervention: Preoperative radiation therapy Comparison: No preoperative radiation therapy
Outcomes № of participants
(studies)
Follow-up Certainty of the evidence
(GRADE) Relative effect
(95% CI) Anticipated absolute effects
Risk with No preoperative radiation therapy Risk difference with Preoperative radiation therapy
Mortality 88 (1 non-randomized study)33 ⨁○○○ Very lowa,b,c OR 0.83 (0.33 to 2.10) 688 per 1,000 41 fewer per 1,000 (267 fewer to 135 more)
Mortality or event 88 (1 non-randomized study)33 ⨁○○○ Very lowa,b,c OR 0.92 (0.39 to 2.17) 604 per 1,000 20 fewer per 1,000 (231 fewer to 164 more)
Relapse 88 (1 non-randomized study)33 ⨁○○○ Very lowa,b,c OR 0.71 (0.27 to 1.86) 292 per 1,000 65 fewer per 1,000 (192 fewer to 142 more)
Incomplete resection 88 (1 non-randomized study)33 ⨁○○○ Very lowa,b OR 0.02 (0.00 to 0.08) 250 per 1,000 243 fewer per 1,000 (250 fewer to 224 fewer)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.