Strengths and limitations
The strengths of the study lay in its prospective design, the large
sample size with statistical justification, and evaluation of several
antibodies against SARS-CoV-2. The limitations of the study were the
lack of serial maternal serology sampling, insufficient sample size for
assessing neonatal complications related to COVID-19 and parental
refusal to allow neonatal SARS-CoV-2 nasopharyngeal swabbing. It should
be noted that only five neonates were born within 2 weeks of maternal
SARS-CoV-2 infection, when serology test sensitivity and specificity
might be lower.