ToC Figure. WisDM, an artificial intelligence-based platform, is harnessed to design and prioritize compound combinations to sustainably increase the yield of Amaranthus cruentus (red spinach). This workflow enables the prioritization of WisDM Green-pinpointed combinations, such as humic acid in combination with seaweed extract, and these combinations were able to achieve 15-35% increase in the biological yield of red spinach.