WisDM Green Compound Combination Optimization
In the WisDM Green design step, a set of 59 compound combinations selected according to a Resolution IV Orthogonal Array Composite Design (OACD) was applied to plants one time only on Day 21 (N = 3) (Figure 2b and Table 6). On day 50, the harvested plants were comprehensively quantified. The biological yield of each plant treated with various combinations of compounds were measured, and normalized to the control plants to determine %Yield (Equation 1 and Figure 5c). A small number of plant samples (16 out of 177) were excluded due to experimental errors, which are described in detail in Statistical Analysis. This set of experiments was performed along with mono-compounds, and the experimental conditions are illustrated in Figure 6.