Conclusion
Our results demonstrated MPM to
be a suitable method to visualize placental tissue and the processing
methodology developed can quantifiably differentiate placental
morphologies. This methodology could be further utilised to phenotype PE
subtypes, and ultimately aid in unravelling the multi-etiological nature
of preeclampsia. In the future, stratification based on 3D placental
morphology could aid in the search for early diagnostic markers and
(preventative) treatment options to improve maternal and foetal
outcomes.