The heat-shock response and transcriptional WGP
The acclimation effect within a generation, commonly known as
heat hardening or heat-shock response, has been widely investigated
across several organisms for decades (Krebs, 1999; Krebs and
Bettencourt, 1999; Hoffmann et al., 2003; Sgrò et al., 2010; Kellermann
and Sgrò, 2018; Diaz et al., 2020). We found that DE genes are linked
to functions that are typical of heat hardening, including the
expression of proteolytic pathways, heat-shock proteins (HSPs), and
other molecular functions that might protect tissues from the damage
caused by high thermal exposures (Dahlgaard et al., 1998; Sørensen et
al., 2005; Bahrndorff et al., 2010; Diaz et al., 2015; Mahat et al.,
2016; Cai et al., 2017). In contrast, AS genes are involved in multiple
structural, cell, and metabolic functions, including muscle assembly, as
well as in different mechanisms of gene regulation, such as spliceosome
activity, chromatin remodeling, and translation regulation.