Clinical and laboratory characteristics of chorioamnionitis and risk of neonatal infection
The association between each clinical or laboratory characteristic and risk of composite neonatal infection is displayed in table 4. Maternal intrapartum persisting temperature between 38.0 and 38.9°C, or a single maternal temperature ≥ 39°C was not associated with an increased risk of neonatal infection. A first leukocyte count in the second tertile was associated with an approximately doubled risk of neonatal infection (adjusted OR 2.14 [95% CI 1.02-4.49]), whereas there was no association between a first leukocyte count in the third tertile and risk of neonatal infection. There was no significant association between highest maximum leukocyte count, or first CRP level, with risk of neonatal infection. Highest CRP in the third tertile was associated with an ~4-folded increased risk of neonatal infection (adjusted OR 4.01 [95% CI 1.66-9.68]). There was a borderline significant association between fetal tachycardia and neonatal infection (adjusted OR 1.99 [95% CI 0.99-4.00]). A positive cervical culture was associated with a doubled risk of neonatal infection (2.22 [95% CI 1.10-4.48]).