Protocol
All evaluations were carried out in a single day. The sickle cell anemia
group (SCAG) was evaluated in the Pediatric Hematology Outpatient Clinic
of Darcy Vargas Children Hospital, Sao Paulo, Brazil, while the CG was
evaluated in public or private schools. Data was performed between
October 2018 and July 2019. The present comorbidities and medications in
use in the SCAG were obtained from medical records and confirmed in the
interview. The mean values of the last three hemoglobin collected in the
last 12 months were used to estimate the basal hemoglobin. The
assessments were carried out in the following sequence: Pediatric
Quality of Life InventoryTM 4.0
(PedsQlTM4.0) quality of life questionnaire,
assessment of lung function (spirometry and respiratory muscle strength)
and functional capacity (modified shuttle test and 5-repetition
sit-to-stand).