Protocol
All evaluations were carried out in a single day. The sickle cell anemia group (SCAG) was evaluated in the Pediatric Hematology Outpatient Clinic of Darcy Vargas Children Hospital, Sao Paulo, Brazil, while the CG was evaluated in public or private schools. Data was performed between October 2018 and July 2019. The present comorbidities and medications in use in the SCAG were obtained from medical records and confirmed in the interview. The mean values of the last three hemoglobin collected in the last 12 months were used to estimate the basal hemoglobin. The assessments were carried out in the following sequence: Pediatric Quality of Life InventoryTM 4.0 (PedsQlTM4.0) quality of life questionnaire, assessment of lung function (spirometry and respiratory muscle strength) and functional capacity (modified shuttle test and 5-repetition sit-to-stand).