Sample Size
The sample size was calculated using the THI minimal clinically
important difference (MCID) of 7 points and a standard deviation (SD) of
1417. However, these values were reconsidered due to
the consequent ineligibility of most tinnitus in-patients followed up by
our otolaryngology service. From the wide range of THI MCID used in
literature for this purpose3,15, we arrived at a more
conservative THI difference of 10 points with a SD of 13, corresponding
to the CGI-I group “minimally better” of Zeman et
al.17 With 80.X% power, 0.05 α level, and a 10.X%
dropout rate, the sample comprised 62 participants.