Common histological and immunohistochemical findings in case 1 and Case 2 ( Fig 2)
Several common histological findings were found both” in vitiligo and in AAG. Melanocytes in the depigmented skin and autofluorescent PC in the gastric mucosa were partially or totally missing . At high magnification we found MITF melanocytes protruding or falling down into the dermis, while several detached and damaged PC were staying within the lamina propria. In both conditions an adhesivity impairment with a down expression of E- Cadherin and of Coll IV was objectivated. MITF + melanocytes falling down into the dermis and the detached PC were surrounded by an infiltrate including CD8 and CD4-T lymphocytes . CD8 were infiltrating the epidermis in close contact with remaining melanocytes and around remaining P.C in gastric mucosa.