Clinical Case n° 2
A 35-year- old male with a generalized vitiligo involving the face, the upper limbs, associated to a thyroid insufficiency and a pernicious anemia was recruited. A gastroscopy was proposed to the patient following the recent discovery of his pernicious anemia and the positive detection of anti parietal cells antibodies . Helicobacter Pylori research was negative. A biopsy was performed at the edge of a vitiligo lesion including depigmented and normally pigmented areas. Skin and gastric samples were stained with HES and immunostained with anti E- Cadherin for assessment of an adhesivity defect, anti Collagen IV for detecting an impairment of basement membrane and CD8 antibodies for evaluating the inflammatory infiltrate. Histological description :infiltration of plasma cells and lymphocytes involving the full thickness of lamina propria with atrophic glandular alteration and in some places » pseudopyloric metaplasia (5)