Methods
For this study, we included antidepressant users of the multicenter
B-PROOF study. Fall incidents were recorded prospectively using fall
calendars. Antidepressant plasma concentrations were analyzed by Liquid
chromatography-mass spectrometry(LC-MS) at baseline and at 2 years
follow-up. The associations between the observed antidepressant
concentration, or concentration change over time (delta) and fall risk
were assessed using Cox proportional hazard and logistic regression
models and adjusted for potential confounders.