Study limitations
The present study has several significant limitations. First, the study was observational. More extensive prospective randomized trials are needed to explore these results and their clinical application. Second, it was performed in a single centre. Third, the response rate for the QoL survey was 87.6%, and data was not available for all patients enrolled in the study. Finally, the present study results should be interpreted as observational and hypothesis-generating only due to their exploratory data analysis nature.