Diagnostic accuracy
Table 3 presents the diagnostic accuracy of MRI in general and the
individual potential predictors of adenomyosis. MRI overall had a
sensitivity of 50.4%, a specificity of 66.9%, a PPV of 55.9%, a NPV
of 61.8%, a positive LR of 1.5, and a negative LR of 0.7. The overall
accuracy was 59.4%. A history of curettage showed an overall accuracy
of 59.7%, with a sensitivity of 22.1%, a specificity of 91.1%, a PPV
of 67.4%, a NPV 58.4%, a positive LR 2.5, and a NLR of 0.9.
Additionally, AUB had a sensitivity of 94.2%, a specificity of 11.1%,
a PPV of 47.9%, and a NPV of 68.8%. The positive LR of AUB was 1.1,
negative LR 0.5, and overall accuracy 49.7%. A JZ Diff ≥ 5 mm on MRI
had an overall accuracy of 54.8%, with a sensitivity of 88.6%, a
specificity of 22.0%, a PPV of 52.5%, a NPV of 66.7%, a positive LR
of 1.1, and a negative LR of 0.5. The sensitivity of the presence of HSI
foci was 40.3%, the specificity was 91.0%, the PPV was 48.4%, and the
NPV was 52.6%. The positive LR was 4.8, the negative LR was 0.7, and
the overall accuracy was 68.1%. Reader (CR and MvdW) detection versus
initial radiologist diagnosis is shown in Table S3.
In tests for individual prognostic diagnostic potential using the
ROC-curve, no continuous variables showed an AUC ≥0.7. Highest AUCs were
found for mean JZ thickness and JZ Max (AUC .624) (data not shown).