1 | INTRODUCTION
Rarely seen, Neonatal Lupus erythematosus (NLE) is characterized by cutaneous lesions and/or congenital heart block in infants at birth or shortly afterwards. This syndrome is linked to the mother’s transplantation of maternal auto antibodies (usually anti Ro/SS-A, La/SS-B or rarely anti-U(1)RNP). Mothers of affected children may have signs of Sjögren’s Syndrome or other Connective Tissue Diseases, or they may be asymptomatic.1
In light of decreasing global fertility rates, numerous nations are implementing measures to encourage higher fertility rates and encourage more families to have a second child.2 Therefore, it is estimated that the incidence rate of NLE in siblings will increase too, so we should raise the awareness of NLE in siblings, which is very important for the monitoring, evaluation, diagnosis and management of NLE.
2 | METHODS We collect clinical data of two siblings with NLE, including their medical history, clinical images, and results from laboratory and pathological examinations. We aim to compare and analyze the differences in clinical manifestations between the siblings, as well as track their prognosis.