Introduction:
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterised by extreme sensitivity to sunlight, resulting in severe sunburn and pigment changes in the skin. It is caused by defects in genes involved in the repair of ultraviolet induced photoproducts in DNA by nucleotide excision repair (NER). It is associated with greatly elevated incidence of skin cancer.1,2 It is also associated with malignancies of oral cavity especially squamous cell carcinoma and haematological malignancy especially acute myeloid leukaemia (AML). 3
Lymphoblastic leukaemia in XP is extremely rare and there are very few case reports of the same2-4. We report a case of a 11-year-old boy with XP, who developed B – Acute lymphoblastic leukaemia (B-ALL).