CONCLUSION
In summary, we developed a population PKPD model for oxypurinol in Hmong participants with gout and/or hyperuricemia who take allopurinol. Body mass and renal function are key determinants for oxypurinol clearance and baseline SU, which aligns with previous findings. We also identified SNPs that can impact the oxypurinol clearance and its SU-lowering effect, which could have clinical importance. Considering all the important covariates, we propose a maintenance dose scheme of allopurinol to achieve target SU in the Hmong population that could help to better manage gout in this population, which exhibits a high prevalence of gout.67,68 The validity of this dosing scheme will require further study. However, we believe this study represents an important step in demonstrating the value of clinical trials including unique, under-represented populations who are at high risk for clinical consequences from hyperuricemia and gout and could benefit from effective ULT.