BLurate , baseline serum urate;fm , fraction of the allopurinol systemically
available as oxypurinol; CL/fm , apparent
clearance of oxypurinol; V/fm , apparent volume of
distribution of oxypurinol; Kfm , combined
absorption and formation rate constant; Imax ,
maximum inhibitory effect of oxypurinol on xanthine dehydrogenase to
inhibit urate production; IC50 , oxypurinol
concentration at half maximum inhibitory effect; CrCL , creatinine
clearance calculated using ideal body weight; FFM, fat free mass;Cssoxy , steady-state plasma oxypurinol
concentration