Works Cited

  1. Amarikwa, L, et al. “Impact of Dean Vortices on the Integrity Testing of a Continuous Viral Inactivation Reactor.” Biotechnology Journal 14.2 (2019): 1700726
  2. Anderson, Neal G. ”Practical use of continuous processing in developing and scaling up laboratory processes.” Organic Process Research & Development 5.6 (2001): 613-621.
  3. Arnold, Lindsay, et al. ”Implementation of fully integrated continuous antibody processing: effects on productivity and COGm.”Biotechnology journal 14.2 (2019): 1800061.
  4. Bisschops, M., Frick, L., Fulton, S., & Ransohoff, T. (2009). Single-use continuous countercurrent multicolumn chromatography.BioProcess International , 7 , 18–23.
  5. Casey, Catherine, et al. ”Protein concentration with single-pass tangential flow filtration (SPTFF).” Journal of membrane science 384.1-2 (2011): 82-88.
  6. Coffman, Jonathan, et al. ”A common framework for integrated and continuous biomanufacturing.” Biotechnology and Bioengineering118.4 (2021): 1735-1749.
  7. Coolbaugh, Michael J., et al. ”Pilot‐scale demonstration of an end‐to‐end integrated and continuous biomanufacturing process.”Biotechnology and Bioengineering (2021).
  8. Croughan, Matthew S., Konstantin B. Konstantinov, and Charles Cooney. ”The future of industrial bioprocessing: batch or continuous?.”Biotechnology and bioengineering 112.4 (2015): 648-651.
  9. Dizon‐Maspat, Jemelle, et al. ”Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production.” Biotechnology and Bioengineering 109.4 (2012): 962-970.
  10. Erickson, John, et al. ”End‐to‐end collaboration to transform biopharmaceutical development and manufacturing.” Biotechnology and Bioengineering (2021).
  11. Godawat, Rahul, et al. ”End-to-end integrated fully continuous production of recombinant monoclonal antibodies.” J Biotechnol213.suppl C (2015): 13-19.
  12. Jungbauer, Alois. ”Continuous downstream processing of biopharmaceuticals.” Trends in biotechnology 31.8 (2013): 479-492.
  13. Klutz, Stephan, et al. ”Developing the biofacility of the future based on continuous processing and single-use technology.” Journal of Biotechnology 213 (2015): 120-130.
  14. Konstantinov, Konstantin B., and Charles L. Cooney. ”White paper on continuous bioprocessing May 20–21 2014 continuous manufacturing symposium.” Journal of pharmaceutical sciences 104.3 (2015): 813-820.
  15. Levison, P. ”Moving one unit operation at a time toward continuous biomanufacturing: an overview of Pall solutions for integrated continuous biopharmaceutical production.” Bioprocess Int 14 (2016): s6-s9.
  16. Nambiar, Anirudh MK, Ying Li, and Andrew L. Zydney. ”Countercurrent staged diafiltration for formulation of high value proteins.”Biotechnology and bioengineering 115.1 (2018): 139-144.
  17. Ötes, Ozan, et al. ”Moving to CoPACaPAnA: implementation of a continuous protein A capture process for antibody applications within an end-to-end single-use GMP manufacturing downstream process.”Biotechnology Reports 26 (2020): e00465.
  18. Mahal, Hanna; Farid, Suzy et al. “End-to-end continuous bioprocessing: Impact on facility design, cost of goods, and cost of development for monoclonal antibodies”. Biotechnology and Bioengineering Volume 118, Issue 9 (2021)
  19. Pollock, James, et al. ”Integrated continuous bioprocessing: Economic, operational, and environmental feasibility for clinical and commercial antibody manufacture.” Biotechnology progress 33.4 (2017): 854-866.
  20. Reay, David, Colin Ramshaw, and Adam Harvey. Process Intensification: Engineering for efficiency, sustainability and flexibility . Butterworth-Heinemann, 2013.
  21. Rucker‐Pezzini, Joanna, et al. ”Single pass diafiltration integrated into a fully continuous mAb purification process.” Biotechnology and bioengineering 115.8 (2018): 1949-1957.
  22. United States, Food and Drug Administration, Center for Biologics Evaluation and Research Center for Drug Evaluation and Research.Q5A Viral Safety Evaluation of Biotechnology Products Derived From Cell Lines of Human or Animal Origin , 1999. Accessed 2021.
  23. Yehl, Christopher J., and Andrew L. Zydney. ”High Performance Countercurrent Membrane Purification for protein separations.”Journal of Membrane Science 633 (2021): 119396.
  24. Zydney, Andrew L. ”Continuous downstream processing for high value biological products: a review.” Biotechnology and bioengineering 113.3 (2016): 465-475.
  25. Angarita, Monica; Morbidelli, Massimo et al. “Twin-column CaptureSMB: a novel cyclic process for protein A affinity chromatography“J. Chromatography A (2015)