Factors associated with successful extubation
Infants who failed extubation had a higher incidence of hemodynamically
significant PDA at extubatio. These infants were also noted to have a
lower gestational age, lower birth weight, higher RSS in first 6 hours
of age, and higher incidence of histological chorioamnionitis. These
infants also had a lower post-menstrual age, lower weight at extubation,
higher receipt of nasal CPAP or non-invasive positive pressure
ventilation (NIPPV) as post extubation respiratory support, lower
pre-extubation pH, and higher pre-extubation
Fio2 (Table 1) .
On logistic regression analysis successful extubation was significantly
associated with absence of hemodynamically significant PDA (Odds Ratio
0.32, 95% Confidence Interval 0.17-0.61) after adjusting for
gestational age, age at extubation, sex, pH at extubation,
Fio2 at extubation and highest RSS in first 6
hours of age.