Results
The present work reanalyses proteomics data available in public
repositories, focusing on elucidating the biological mechanisms that
support MTK’s repurposing for AD management. With that purpose, 1) data
obtained from different tissues (brain, hippocampus, and prefrontal
cortex) collected from mice treated orally with daily doses of 1 mg
kg-1 MTK for one week (Marques et al. , 2022b),
and 2) data obtained from chicken embryo neurons exposed to 1 and 5 μM
MTK for 48 h (Marques et al. , 2022a) were thoroughly revisited.
Brain proteomics from MTK-treated
mice
Proteomics data from mouse brain tissue (Figure 1A) show that MTK is
able to up-regulate the neutral cholesterol ester hydrolase 1 (Nceh1,
3.33-fold higher in MTK-treated mice) and the transcription factor
HIVEP3 (3.32-fold higher in MTK-treated mice).