Results

The present work reanalyses proteomics data available in public repositories, focusing on elucidating the biological mechanisms that support MTK’s repurposing for AD management. With that purpose, 1) data obtained from different tissues (brain, hippocampus, and prefrontal cortex) collected from mice treated orally with daily doses of 1 mg kg-1 MTK for one week (Marques et al. , 2022b), and 2) data obtained from chicken embryo neurons exposed to 1 and 5 μM MTK for 48 h (Marques et al. , 2022a) were thoroughly revisited.

Brain proteomics from MTK-treated mice

Proteomics data from mouse brain tissue (Figure 1A) show that MTK is able to up-regulate the neutral cholesterol ester hydrolase 1 (Nceh1, 3.33-fold higher in MTK-treated mice) and the transcription factor HIVEP3 (3.32-fold higher in MTK-treated mice).