FIGURE 2 HERE
Figure 2. Altered proteins with an important role in Alzheimer’s disease
identified in chicken embryo neurons. This figure illustrates the
heatmap of identified altered proteins (p < 0.05 and at
least 1.5‑fold change) in mature isolated embryonic-chicken neurons
exposed to 5 μM MTK. The LFQ intensity scale represents the normalised
relative quantification across all samples. Image adapted from Marqueset al. (2022d), with permission from Elsevier.
To conclude, a wide range of proteins were altered in both model systems
(mouse and chicken embryo neurons) and some of these have a direct
contribution to the processes involved in neurodegenerative disorders,
mainly in the aggregation of proteins associated with Alzheimer’s and
Parkinson’s diseases.