Table 1: Demographic and Clinical Characteristics
Patient Characteristics Patient Characteristics ICI +SBRT (n=16) ICI (n=5)
Gender (n) Female 9 3
Male 7 2
Race (n) Caucasian 13 4
African American 1 0
Other 2 1
Age (years) Mean; Range 48.5; 22-81 56+11; 26-67
KPS (n) >70 14 3
<70 2 2
Initial Resection Extent (n) Gross Total Resection 9 1
Subtotal Resection 4 3
Biopsy 3 1
WHO Tumor grade (n) 4 10 2
3 6 3
MGMT methylation status (n) Methylated 4 1
Unmethylated 12 4
IDH mutation status (n) Mutated 3 0
Wild type 0 5
TERT promotor mutation (n) Mutated 10 2
Wild type 0 3
Adjuvant TMZ + radiation (n) Yes 12 4
No 4 1
Lines of therapy (including TMZ + radiation) Mean; Range 4.5+1.7; 2-8 4.4+1.6; 3-7
Abbreviations: KPS: Karnofsky Performance Status; WHO: World Health Organization; MGMT: O6-Methylguanine-DNA Methyltransferase; IDH: isocitrate dehydrogenase; TERT: telomerase reverse transcriptase gene promoter; TMZ: temozolomide Abbreviations: KPS: Karnofsky Performance Status; WHO: World Health Organization; MGMT: O6-Methylguanine-DNA Methyltransferase; IDH: isocitrate dehydrogenase; TERT: telomerase reverse transcriptase gene promoter; TMZ: temozolomide Abbreviations: KPS: Karnofsky Performance Status; WHO: World Health Organization; MGMT: O6-Methylguanine-DNA Methyltransferase; IDH: isocitrate dehydrogenase; TERT: telomerase reverse transcriptase gene promoter; TMZ: temozolomide Abbreviations: KPS: Karnofsky Performance Status; WHO: World Health Organization; MGMT: O6-Methylguanine-DNA Methyltransferase; IDH: isocitrate dehydrogenase; TERT: telomerase reverse transcriptase gene promoter; TMZ: temozolomide