Data and Statistical Analysis
Descriptive statistics were used to summarize patient demographics,
diagnoses, and treatment characteristics. Platelet counts at baseline
were compared with platelet counts at one, two, three, and four weeks
after TPO-RA initiation using the exact Wilcoxon signed-rank test. Given
the multiple comparisons across time points, a Benjamini-Hochberg
correction was used to control the false discovery rate, with an
adjusted p-value of <0.05 considered statistically significant.
Platelet transfusion requirements before and after TPO-RA initiation
were also compared using the exact Wilcoxon signed-rank test. Adverse
events, including drug-related toxicities and bleeding events, were
recorded and analyzed. All statistical analyses were conducted in R.