Data and Statistical Analysis
Descriptive statistics were used to summarize patient demographics, diagnoses, and treatment characteristics. Platelet counts at baseline were compared with platelet counts at one, two, three, and four weeks after TPO-RA initiation using the exact Wilcoxon signed-rank test. Given the multiple comparisons across time points, a Benjamini-Hochberg correction was used to control the false discovery rate, with an adjusted p-value of <0.05 considered statistically significant. Platelet transfusion requirements before and after TPO-RA initiation were also compared using the exact Wilcoxon signed-rank test. Adverse events, including drug-related toxicities and bleeding events, were recorded and analyzed. All statistical analyses were conducted in R.