BDZ-exposure
In 26.5% of the pregnancies, exposure to BDZ was in at least the first trimester, while the exposure was in at least the third trimester (91.8%). In 20.4%, exposure occurred in all trimesters.
We found no differences in both groups regarding birth weight, APGAR scores at 1, 5 and 10 minutes and the number of minor and major malformations. BDZs exposure was associated with a decreased number of gestational days (duration of pregnancy) of -3.2 days, 95% CI -5.8 - -0.53, p = 0.019. In the final regression model, also gestational diabetes, preeclampsia or HELLP syndrome, maternal infections, placental disease, meconium containing amnion fluid, lower birth weight and appearance of minor malformations were relevant factors for decreased number of gestational days. See table 2 for details. The factors APGAR score at 1 and 5 minutes seems not logically related to number of gestational days.
BDZs exposure was associated with prolonged psychiatric care, which was defined as more than 3 months psychiatric care after delivery, OR 2.511, 95% CI 1.675-3.782, p<0.001. Other factors in the model were maternal age, male gender of the newborn and birthweight, see table 3 for details.
We found no differences between minor malformations between the exposed and control group with a crude OR = 1.852 (95% CI 0.897, 3.822), and also no differences in major malformations with a crude OR = 0.652 (95% CI 0.253, 1.680).