Single transplant: CS at diagnosis and end of induction
Though the focus of this report is on recipients of tandem transplant, a
sub-analysis was performed to permit assessment of the CS cut point in a
contemporaneously treated group of patients randomized to undergo a
single AHCT (n=99) on ANBL0532 (Supplemental TABLE S1) . The
optimal CS cut point at diagnosis was 21, with a median CS of 15 (range
1-28) (Supplemental Table S2) . The 3-year EFS for patients with
CS< 21 (n=72) vs >21 (n=27) at diagnosis
was 51.0±6.0% vs 34.9±9.4%; p=0.04 (Supplemental FIGURE
S3A-C) .
At EOI, the optimal EOI CS cut point was 2, with a median CS=0 (range
0-21). However, the difference in EFS for patients with
CS< 2 (n=81) vs CS>2 (n=18) at EOI was not
statistically significant, with 3-year EFS 46.5±5.6% vs 29.5±11.1%;
p=0.29 (Supplemental Figure S3D-F) .