ABSTRACT:
Multiomics approaches to studying systems biology are very powerful
tools that can elucidate changes in the genomic, transcriptomic,
proteomic, and metabolomic levels within a particular cell type in
response to an infection. These approaches are valuable for
understanding the mechanisms behind disease pathogenesis, and
specifically how the immune system responds to being challenged. With
the emergence of the COVID-019 pandemic, now more than ever, the
importance and utility of these tools has become evident in garnering a
better understanding of the systems biology within the innate and
adaptive immune response and for developing treatments and preventative
measures for new and emerging pathogens that pose a threat to human
health. In this review, we focus on the various state of the art
“omics” technologies within the scope of innate immunity.
KEYWORDS: Innate immunity, mass spectrometry, cellular
signaling, omics, systems immunology
INTRODUCTION: