This study aimed to investigate the relationship between arsenic exposure (as measured in urine) and both allostatic load and cardiovascular disease (CVD) risk markers within a representative group of participants from the U.S. noninstitutionalized civilian population. The results revealed individuals with high arsenic levels were significantly older than those with lower arsenic levels. Other findings indicated no significant associations between cardiovascular variables by degree of arsenic exposure as measured by total urinary arsenic. These results underscore the need to assess numerous biomarkers when examining the potential health implications of exposure to arsenic as markers of longer-term Arsenic exposure or consideration of specificity of arsenic species   may have yielded different results.