Conclusion
Compared to BVP, LBBP is associated with, a greater improvement in LV systolic function, and a lower rate of heart failure-related hospitalization from this meta-analysis. Dedicated large randomized controlled trials are needed to further elucidate the comparative long-term efficacy and safety of LBBP CRT vs. BIV CRT.
References:
1. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Nov 10 2018;392:1789-1858.
2. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation Feb 23 2010;121:e46-e215.
3. Baldasseroni S, Gentile A, Gorini M, Marchionni N, Marini M, Masotti G, Porcu M, Maggioni AP. Intraventricular conduction defects in patients with congestive heart failure: left but not right bundle branch block is an independent predictor of prognosis. A report from the Italian Network on Congestive Heart Failure (IN-CHF database). Ital Heart J Sep 2003;4:607-613.
4. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022;145.
5. McAlister FA, Ezekowitz J, Hooton N, Vandermeer B, Spooner C, Dryden DM, Page RL, Hlatky MA, Rowe BH. Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systematic review. Jama Jun 13 2007;297:2502-2514.
6. Zareba W, Klein H, Cygankiewicz I, et al. Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Circulation Mar 15 2011;123:1061-1072.
7. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L. The effect of cardiac resynchronization on morbidity and mortality in heart failure. The New England journal of medicine Apr 14 2005;352:1539-1549.
8. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM. Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure. New England Journal of Medicine 2004/05/20 2004;350:2140-2150.
9. Daubert C, Behar N, Martins RP, Mabo P, Leclercq C. Avoiding non-responders to cardiac resynchronization therapy: a practical guide. European heart journal May 14 2017;38:1463-1472.
10. Hummel JD, Coppess MA, Osborn JS, Yee R, Fung JW, Augostini R, Li S, Hine D, Singh JP. Real-World Assessment of Acute Left Ventricular Lead Implant Success and Complication Rates: Results from the Attain Success Clinical Trial. Pacing Clin Electrophysiol Nov 2016;39:1246-1253.
11. Huang W, Su L, Wu S, Xu L, Xiao F, Zhou X, Mao G, Vijayaraman P, Ellenbogen KA. Long-term outcomes of His bundle pacing in patients with heart failure with left bundle branch block. Heart Jan 2019;105:137-143.
12. Lewis AJM, Foley P, Whinnett Z, Keene D, Chandrasekaran B. His Bundle Pacing: A New Strategy for Physiological Ventricular Activation. Journal of the American Heart Association 2019;8:e010972.
13. Vinther M, Risum N, Svendsen JH, Møgelvang R, Philbert BT. A Randomized Trial of His Pacing Versus Biventricular Pacing in Symptomatic HF Patients With Left Bundle Branch Block (His-Alternative). 2021;7:1422‐1432.
14. Sharma PS, Dandamudi G, Herweg B, Wilson D, Singh R, Naperkowski A, Koneru JN, Ellenbogen KA, Vijayaraman P. Permanent His-bundle pacing as an alternative to biventricular pacing for cardiac resynchronization therapy: A multicenter experience. Heart rhythm 2018;15:413-420.
15. Huang W, Su L, Wu S, Xu L, Xiao F, Zhou X, Ellenbogen KA. A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block. Can J Cardiol Dec 2017;33:1736 e1731-1736 e1733.
16. Vijayaraman P, Ponnusamy S, Cano Ó, et al. Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: Results From the International LBBAP Collaborative Study Group. JACC Clinical electrophysiology 2021;7:135-147.
17. Wang Y, Zhu H, Hou X, et al. Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy. Journal of the American College of Cardiology 2022/09/27/ 2022;80:1205-1216.
18. Strocchi M, Lee AWC, Neic A, et al. His-bundle and left bundle pacing with optimized atrioventricular delay achieve superior electrical synchrony over endocardial and epicardial pacing in left bundle branch block patients. Heart rhythm 2020;17:1922-1929.
19. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Bmj Jul 21 2009;339:b2535.
20. Medicine ISo. Program for the Protection of Human Subjects / Institutional Review Board. 2023;https://icahn.mssm.edu/about/faculty-resources/handbook/research/irb, 2023.
21. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj Sep 6 2003;327:557-560.
22. Wu S, Su L, Vijayaraman P, Zheng R, Cai M, Xu L, Shi R, Huang Z, Whinnett ZI, Huang W. Left bundle branch pacing for Cardiac Resynchronization Therapy: non-randomized on treatment comparison with His Bundle Pacing and Biventricular Pacing. 2020.
23. Gu Y, Li Y, Zhu Y, Lin X, Tian T, Zhang Q, Gong J, Wang L, Li J. Cardiac resynchronization therapy in heart failure patients by using left bundle branch pacing. Frontiers in cardiovascular medicine 2022;9:990016.
24. Feng XF, Yang LC, Zhao Y, Yu YC, Liu B, Li YG. Effects of adaptive left bundle branch-optimized cardiac resynchronization therapy: a single centre experience. BMC Cardiovasc Disord Aug 6 2022;22:360.
25. Vijayaraman P, Cano O, Ponnusamy SS, et al. Left bundle branch area pacing in patients with heart failure and right bundle branch block: Results from International LBBAP Collaborative-Study Group. Heart Rhythm O2 2022;3:358-367.
26. Sharma PS, Patel NR, Ravi V, et al. Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing: Results from the Geisinger-Rush Conduction System Pacing Registry. Heart Rhythm Jan 2022;19:3-11.
27. Okubo Y, Miyamoto S, Uotani Y, Ikeuchi Y, Miyauchi S, Okamura S, Tokuyama T, Nakano Y. Clinical impact of left bundle branch area pacing in heart failure with preserved ejection fraction and mid-range ejection fraction. Pacing Clin Electrophysiol Apr 2022;45:499-508.
28. Padala SK, Master VM, Terricabras M, Chiocchini A, Garg A, Kron J, Shepard R, Kalahasty G, Azizi Z, Tsang B, et al. Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing: a Multicenter Prospective Study. 2020.
29. Ravi V, Hanifin JL, Larsen T, Huang HD, Trohman RG, Sharma PS. Pros and Cons of Left Bundle Branch Pacing: A Single-Center Experience. Circulation Arrhythmia and electrophysiology 2020;13:e008874.
30. Su L, Wang S, Wu S, Xu L, Huang Z, Chen X, Zheng R, Jiang L, Ellenbogen KA, Whinnett ZI, Huang W. Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study. Circulation Arrhythmia and electrophysiology 2021;14:e009261.
31. Vijayaraman P, Zalavadia D, Haseeb A, et al. Clinical outcomes of conduction system pacing compared to biventricular pacing in patients requiring cardiac resynchronization therapy. Heart rhythm 2022;19:1263-1271.
32. Jastrzębski M, Kiełbasa G, Cano O, et al. Left bundle branch area pacing outcomes: the multicentre European MELOS study European heart journal 2022;43:4161-4173.
33. Pujol-Lopez M, Jiménez-Arjona R, Garre P, et al. Conduction System Pacing vs Biventricular Pacing in Heart Failure and Wide QRS Patients. JACC: Clinical Electrophysiology 2022/11/01 2022;8:1431-1445.
34. Liang Y, Wang J, Gong X, et al. Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure. Circulation Arrhythmia and electrophysiology Oct 28 2022e011181.
35. Liu W, Hu C, Wang Y, Cheng Y, Zhao Y, Liu Y, Zheng S, Chen H, Shu X. Mechanical Synchrony and Myocardial Work in Heart Failure Patients With Left Bundle Branch Area Pacing and Comparison With Biventricular Pacing. Frontiers in cardiovascular medicine 2021;8:727611.
36. Vijayaraman P, Herweg B, Verma A, et al. Rescue left bundle branch area pacing in coronary venous lead failure or nonresponse to biventricular pacing: Results from International LBBAP Collaborative Study Group. Heart rhythm 2022;19:1272-1280.
37. Glikson M, Nielsen JC, Kronborg MB, et al. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA). European heart journal 2021;42:3427-3520.
38. Cheng L, Zhang J, Wang Z, Zhou M, Liang Z, Zhao L, Chen J, Wu Y. Efficacy and safety of left bundle branch area pacing versus biventricular pacing in heart failure patients with left bundle branch block: study protocol for a randomised controlled trial. 2020;10.