Limitations
Our meta-analysis had several limitations: First, only one study
included in our analysis was a randomized control trial and the other 9
were observational studies, which can potentially introduce confounding
factors and compromise the interpretation of results. Second, all 10
studies had a relatively small sample size and short follow-up period,
limiting the power to assess the long-term outcome and safety of LBBP.
Third, the definition and classification of data reporting in different
studies varies (e.g. definition of implant success, use of BNP versus
N-terminal-pro BNP, etc.) thereby limiting further data extraction and
analysis.