Background: Epidemiological evidence hints at a connection between thyroid dysfunction and chronic spontaneous urticaria (CSU), but the causality is obscure. This study applies a two-sample Mendelian randomization (MR) method to explore the causality between them. Methods: We utilized bidirectional MR to explore the causality between CSU and thyroid autoimmunity in Europeans and East Asians. The SNPs examined in this study were sourced from the Open GWAS database, the ThyroidOmics Consortium, the FinnGen Consortium, and BioBank Japan. In the forward MR analysis, we considered thyroid dysfunction, AITD, and thyroid function indicators—FT3, FT4, TT3, ln (FT3/FT4), ln (TT3/FT4), TSH and TPOab—as exposures, with CSU as the outcome in a cohort of 398,763 individuals. Conversely, in the reverse MR analysis, CSU served as the exposure, and thyroid function phenotypes were the outcomes. The primary analytical method was IVW, complemented by sensitivity analyses to evaluate pleiotropy and robustness. Results: IVW analysis indicates that genetic predisposition to thyroid disorders is linked to increase CSU risk in Europeans, with significant odds ratios noted for Graves’ disease, hyperthyroidism, and Hashimoto’s disease. Reverse MR suggests possible causal links between a genetic propensity for CSU and a decrease in hyperthyroidism and the ln (FT3/FT4) ratio. No evidence was found linking thyroid function phenotypes with CSU in East Asians. Conclusion: Our research indicates that genetic susceptibilities to thyroid disorders are associated with a higher risk of CSU in European populations, with no observed link in East Asian populations. These findings may offer new avenues for future investigation into the relationship between thyroid autoimmunity and CSU.

Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. Nasal polyps (NPs) is one of the main manifestations which cause diverse clinical symptoms of CRS. We conducted a bibliometric and visual analysis of CRS and NPs articles published between 2003 and 2022 to provide researchers with the current state of research and potential directions. Method: We used a systematic search strategy to search relevant articles in the databases of the Web of Science from 2003 to 2022. VOSviewers, Bibliometrix R package, and CiteSpace were used to perform the bibliometric analysis. Results: 3,907 publications, including 3,266 “articles” and 641 “reviews” were retrieved. The USA made the highest contributions to global research, followed by China; furthermore, Northwestern University, Capital Medical University, and Sun Yat-Sen University had the highest number of publications. A total of 12,894 authors participated in this research, with the most published author being Bachert C., followed by Schleimer Robert P. and Schlosser Rodney J.. And the authors with the most co-citations were Bachert C., Fokkens W.J., and Gevaert P. 428 journals had published the articles of this research. Moreover, the journal with the most publications was the International Forum Of Allergy & Rhinology and the Journal Of Allergy And Clinical Immunology received the most citations. “Covid-19”, “biologic”, and “type 2 inflammation” were the top current research hotspots. Conclusion: The United States and Northwestern University were the leading country and institution in researching CRS and NPs. And Bachert C. is the most influential expert. The International Forum Of Allergy & Rhinology published the most articles, and the Journal Of Allergy And Clinical Immunology got the highest number of citations. Moreover, “Covid-19”, “biologic”, and “type 2 inflammation” were the trending topics.