Characteristics -<6 years of age (N=50) 6 to 12 years of age (N=70) P- value
Sex, male, n (%) 22(44.00%) 36(51.43%) ns
Age (y), mean ± SD 4.35±3.20 (2-5 years) 9.07±1.67 (6-12 years) <0.0001
Weight (kg), range 18.01(12.00-25.00) 35.00(20.00-67.00) <0.0001
BMI (kg/m2), mean ± SD 16.22(±2.45) 17.98(±3.27) 0.0102
Duration of AD (y), mean ± SD 3.20(±1.52) 5.83(±2.95) <0.0001
Extrinsic status, n (%) 43(86.00%) 66(94.29%) ns
Phenotypes, n (%)
Erythemato-desquamative 18(36.00%) 23(32.86%) ns
Head and neck dermatitis 15(30.00%) 20(28,57%) ns
Lichenification 7(14.00%) 13(18.57%) ns
Exudative eczema 7(14.00%) 10(14.29%) ns
Prurigo nodularis-like 3(6.00%) 4(5.71%) ns
Family History of Allergy, n (%) 17(34.00%) 20(28.57%) ns
Atopic/allergic diseases concomitant, n (%) 28(56.00%) 42(60.00%) ns
Allergic rhinitis 14(28.00%) 20(28.57%)
Asthma 5(10.00%) 7(10.00%)
Allergic conjunctivitis 0 3(4.29%)
Urticaria 2(4.00%) 1(1.43%)
History of systemic medication for AD, n (%) 50(100.00%) 70(100.00%) ns
Systemic corticosteroids 0 4(5.71%)
Antihistamines 50(100.00%) 70(100%)
Non-steroidal immunosuppressants 0 0
Traditional Chinese medicine 10(20.00%) 19(27.14%) ns
History of topical medication for AD, n (%) 50(100%) 70(100%) ns
Topical corticosteroids 50(100%) 70(100%)
Topical calcineurin inhibitors 35(70.00%) 50(71.43%)
Phosphodiesterase 4 (PDE4) inhibitors 9(18.00%) 9(12.86%)
Concomitant topical medications, n (%) 27(54.00%) 39(55.71%) ns
Topical corticosteroids 16(32.00%) 2840.00%)
Topical calcineurin inhibitors 12(24.00%) 20(28.57%)
Phosphodiesterase 4 (PDE4) inhibitors 4(8.00%) 4(5.71%)
Comorbidities, n (%) 2(4.00%) 3(4.29%) ns
Chronic hepatitis B 0 1(1.43%)
Alopecia areata 0 1(1.43%)
Epilepsy 0 1(1.43%)
Eosinophilic esophagitis 1(2.00%) 0
Vitiligo 1(2.00%) 0
Total IgE level (IU/ml) at baseline, mean ± SD 1663.32(±2353.16) 1698.90(±2711.52) ns
Number of circulating eosinophils (×10^9/L), mean ± SD 0.67(±0.49) 0.69(±0.56) ns
Clinical scores at baseline, mean ± SD
IGA 3.80(±0.40) 3.67(±0.47) ns
SCORAD 51.33(±13.95) 53.18(±18.21) ns
EASI 18.81(±12.39) 19.27(±14.84) ns
CDLQI (IDQoL)* 10.20(±4.62) 10.86(±6.90) ns