AUTORSHIP CONTRIBUTIONS
T.M.H.J.G. enrolled patients, performed blood sampling for PK analysis
and validation and collected in the OPTI-CLOT TARGET study. Patient
inclusion in the UK EHL registry was monitored by M.M., P.W.C.,
C.R.M.H., R.C.T., C.B., S.M., B.M., G.E., B.B., N.C., J.P., and S.A.
T.M.H.J.G. collected data from the UK-EHL registry and checked all
clinical data from the EHL registry. S.F.K. and R.A.A.M. performed the
analysis and developed the population pharmacokinetic model. S.F.K. and
T.M.H.J.G. wrote the manuscript. L.H.B., M.H.C. and R.A.A.M. supervised
the study. All authors contributed substantially to the critical
revision of the manuscript and approved the final draft.