Fig. 3. SARS-CoV-2 Omicron BA.5/ancestral specific T cell response and antibody neutralization ratios. Individual data points comprise the ratio of Omicron BA.5 to ancestral (A, C) T cell responses or (B, D) serum neutralization activity. Recent Omicron BA.5 infection and bivalent booster vaccination are presented as positive (+) or negative (-). (A-B) At T1, HCWs were divided into two groups based on recent (i.e., <3 months) Omicron BA.5 infection. (C-D) At T2, HCWs were divided into four groups based on recent Omicron BA.5 infection and receiving a bivalent booster vaccination. Absolute values that were used to calculate these ratios are presented in Supplementary Fig. 1A-D . Data are represented as median with IQR and were assessed by a (A-B) Mann-Whitney U test or (C-D) Kruskal-Wallis test with Dunn’s post hoc analysis.