Adult-onset hypothyroidism impairs normal brain function. Research on
animal models of hypothyroidism has revealed critical information on how
deficiency of thyroid hormones impacts the electrophysiological and
molecular functions of the brain, which lead to the well-known cognitive
impairment in untreated hypothyroid patients. Currently, such
information can only be obtained from experiments on animal models of
hypothyroidism. This review summarizes important research findings that
pertain to understanding the clinical cognitive consequences of
hypothyroidism.