Introduction
Pyoderma gangrenosum (PG) is an infrequent kind of inflammatory skin
disease that may lead to the development of swiftly expanding and
distressing skin ulcers(1). The initial documentation of PG was
conducted by Dr. Louis Brocq in 1916. However, it was not until the
1930s that Dr. Brunsting characterized a series of patients with
identical clinical symptoms(2). The etiology of PG remains unclear;
however, it is hypothesized to be an autoimmune condition characterized
by the immune system’s attacks on healthy tissue, resulting in the
development of ulcerations.PG impact individuals of all gender, race, or
ages, albeit with a higher incidence rate among adults and a greater
prevalence among the female (3).
PG is correlated with fundamental medical conditions, including
inflammatory bowel disease (IBD), rheumatoid arthritis, lupus, and
specific blood disorders. It is plausible for it to manifest consequent
to pharmaceutical administration or subsequent to surgical intervention
or physical injury(4).The concurrent development of PG with systemic
lupus erythematosus (SLE) is an infrequent phenomenon, with only a
limited number of cases having been documented.
PG can be classified into multiple groups, which include:
1.Classic PG: The prevalent manifestation which is distinguished by the
prompt emergence of distressing ulcers featuring elevated, purple
borders
2.Bullous PG: This form can be identified by the emergence of vesicles
containing fluid that rapidly disintegrates, forming ulcers.
3.Pustular PG: This form can be recognized by the appearance of multiple
small pustules that amalgamate to create distressing ulcers.
4.Vegetative PG: This class stands out by the emergence of skin lesions
resembling cauliflower growths that pose a challenge for effective
management.
5.Postoperative PG: This type manifests after surgical procedures and is
believed to be associated with skin trauma or injury.
6.Systemic PG: The last form is linked with systemic illnesses, such as
rheumatoid arthritis and rarely SLE(5).
The clinical manifestations of PG include the emergence of one or
multiple painful, swiftly advancing ulcers or lesions with uneven
margins and a necrotic core. It is noteworthy that the clinical
manifestation of PG has the potential to resemble other medical
conditions, including infections, malignancies, or autoimmune disorders.
Therefore, an accurate diagnosis necessitates a comprehensive medical
assessment(3).
PG is a condition that can be effectively managed through various
treatment modalities which may encompass corticosteroids,
immunosuppressive medications, antibiotics, and surgical intervention.
Timely medical intervention is crucial in cases of PG, as prompt
treatment can mitigate the risk of complications and enhance prognosis.