DISCUSSION
PG is an uncommon kind of inflammatory skin disease that is not caused
by an infection and is characterized by painful necrotic ulcers that
often appear on the legs(6). It is believed that PG is an autoimmune
disease; however, the exact cause of the disease is not completely
known.
Although PG is frequently linked with systemic conditions such as
inflammatory bowel disease, rheumatoid arthritis, and hematologic
malignancies, the incidence of PG as a prior symptom of SLE is very
uncommon and has only been described in a few individuals to this
point(7).
The identification of PG is established through the process of excluding
other potential sources of cutaneous ulcerations that present with
similar characteristics, such as infections, cancers,
vasculitides, venous insufficiencies, and trauma(8).
To date, in the majority of cases that have been documented, before the
manifestation of PG symptoms, a diagnosis of SLE was made. H. B. Kwon et
al. delineated the clinical manifestation of PG in a female patient aged
35 years, who exhibited the characteristic symptom of painful ulcers on
her lower extremities as our case. The subsequent assessment indicated
that the patient also presented with SLE, posited as the fundamental
etiology of her dermatological manifestation. They deliberate on the
plausible mechanisms that connect the two aforementioned conditions and
underscore the significance of prompt identification and
intervention(9).
In another case study, S. N. Jha et al. demonstrated a female patient,
aged 30 years, diagnosed with SLE, presented with PG affecting her lower
limbs. The authors delve into the plausible immunological mechanisms
that underlie this correlation and emphasize the significance of
interdisciplinary administration(10).