Conclusion
The real prevalence of SC is probably underestimated given the recent histological reclassification of salivary gland tumors, and molecular profiling testing is generally recommended. As no clear cut morphological signs characterizing this neoplasm have as yet been identified, FISH analysis with the NTRK3 probe is recommended when there are morphological signs pointing to the hypothesis of a differential diagnosis. The FISH technique could alternatively be carried out whenever the morphology of the lesion could be indicative of a mucoepidermoid or an ACC carcinoma. The biological behavior of the former can present a variety of characteristics but its high grade of aggressiveness with respect to the latter leads us to suggest that it is best to carry out elective treatment of the lymph nodes of the neck and adjuvant radiotherapy in situations of greater risk.
Figure 1: Secretory carcinoma . A - At low power, secretory carcinoma (left side) appears as a nodule with pushing and well defined borders toward the normal salivary gland (right side) (Hematoxylin&Eosin, 10X). B- at higher magnification, the microhistological architecture is appreciable as numerous microcysts bordered by plump epithelial cells with intraluminal secretion (Hematoxylin&Eosin, 40X). C- The secretory material in the microcyst lumen is highlighted by PAS (Periodic Acid Shift) diastase digestion resistant staining (PAS-D, 40X)