Identification of putative transcription factor binding sites present in 4.3kb SV.
To check the possible role of this SV in gene regulation, we analysed the DNA sequence of the 4.3kb SV using the CiiiDER software (Gearing et al., 2019). CiiiDER uses the MATCH algorithm to predict the transcription factor binding sites in a query set of DNA sequences. First, the JASPAR CORE non-redundant vertebrate transcription factors (Mathelier et al., 2016) were used as the position frequency matrix PFM transcription factor model. Then we selected transcript factors like Aryl hydrocarbon receptor (Ahr), Muscle aponeurosis fibromatosis (Maf), previously implicated in xenobiotic response (Amezian, Nauen, & Le Goff, 2021; Kalsi & Palli, 2015).