5. Conclusion
Our findings conclusively demonstrate that giving flavonoids to mice
with UVB irradiation-induced hyperthyroidism caused a drop in thyroid
hormone levels. Finally, one of the test flavonoids, naringin, may be
able to reverse the changes induced by UVB exposure. UVB exposure has
significant negative impacts on thyroid function and weight. When the
thyroid and body weight are out of balance, naringin can control them
while simultaneously acting as a scavenger. The study also indicates how
naringin has antioxidant capabilities that can reduce ROS, enhance
antioxidant status via free radical scavenging pathways, and quench ROS
to protect against UVB irradiation-induced hyperthyroidism. Our study’s
results are novel to demonstrate how naringin can protect male mice
against UVB-induced hyperthyroidism and prevent the deformation of
thyroid follicles and the alterations in the expression of THRβ-1,
caspase-3 and NOS-2 antibodies. As a result, naringin has a potential
antioxidant and anti-apoptosis and anti-inflammation activity and is a
strong medication for the treatment of hyperthyroidism. Clarifying the
chemical mechanisms that result in naringin’s antioxidant,
anti-apoptosis and anti-inflammation effect will require more study. The
findings suggest that environmental toxicants like radiations effect the
endocrine systems and disturbed the metabolism thus when evaluating
foods for potential health benefits, it may be important to characterise
the naringin concentration of such foods.