3.6. Immunohistochemistry of Thyroid gland showing
expression of THRβ-1, Caspase-3 and NOS-2
There was a marked reduction in the expression of THRβ-1 receptor in the
thyroid of UVB exposed mice as compared to control. The thyroid of
naringin treated showed similar TRHβ-1 receptor expression like that in
the thyroid of control rats (Fig. 7). Moreover, the level of caspase-3
protein expression was significantly increased in UVB exposed mice
compared to the expression in control. The intensity of activated
caspase-3 immunostaining (deep brown) is pre-dominant on thyroid
follicular disruption (Fig. 8). The expression of NOS-2 was seen to be
increased in UVB exposed group as compared to control. The group of
naringin treated showed the intensity of NOS-2 antibody somewhat similar
to control (Fig. 9).