Abstract
Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s
granulomatosis, is a necrotizing vasculitis characterized by small to
medium-sized vessel involvement and the presence of antineutrophil
cytoplasmic antibodies (ANCA). We present a case of a 26-year-old Asian
female who was transferred to our center from a nearby hospital, where
she presented with shortness of breath, tested positive for COVID-19,
and was being managed for COVID-19 pneumonia. She also had hemoptysis,
skin lesions, and left foot numbness. Serological markers and
VATS-guided lung biopsy confirmed the diagnosis. Treatment with
methylprednisolone and rituximab led to stabilization, despite
complications of subcutaneous emphysema and lower extremity neuropathic
symptoms. Early recognition and appropriate management of GPA are
crucial for optimal outcomes.