Introduction
Primary Sjogren’s syndrome (SS) is a systemic autoimmune disorder
commonly characterized by dryness of the eyes and mouth due to
inflammation and subsequent pathology of the lacrimal and salivary
glands. The hallmark feature of SS is exocrinopathy, which frequently
results in xerostomia and keratoconjunctivitis sicca, accompanied by
fatigue and joint pain. Although extra-glandular manifestations are
rare, they can affect musculoskeletal, renal, pulmonary, and
hematological systems. SS should be considered in the differential
diagnosis of idiopathic cytopenia and actively investigated through
patient history, Schirmer’s test, and autoantibody screening. Cytopenia
in primary SS is uncommon, with few cases reported in the literature.
Here, we present the case of a 60-year-old woman with persistent
unexplained bicytopenia (anemia and thrombocytopenia). After a
comprehensive evaluation, she was diagnosed with SS.