Rhodium-Catalyzed Asymmetric Transfer Hydrogenation of Heterocyclic Diaryl Ketones: Facile Access to Key Intermediate of Baloxavir Li Wang,a Renwei Xiao,a Jingyuan Song, a Long-Sheng Zheng,a Qiwei Lang,*,a Gen-Qiang Chen*,b and Xumu Zhang*,a,c Chin. J. Chem. 2023, 41, XXX—XXX. DOI: 10.1002/cjoc.202300XXX
Herein, we have developed a highly practical and enantioselective rhodium-catalyzed asymmetric transfer hydrogenation of heterocyclic diaryl ketones, providing the desired product with up to >99 yield and >99% ee. The synthetical potential of the current reaction was demonstrated by the gram-scale synthesis of key intermediate of baloxavir.