Investigation of various therapeutic approaches and advertisement of
their applications in patients with granulomatosis with polyangiitis
Abstract
Background: Idiopathic granulomatous mastitis is common in Asian
countries, particularly during the childbearing years. Aims: Multiple
approaches have been suggested, including medical management and
surgical intervention, but there is no consensus among experts regarding
the preferred approach for patients with granulomatous mastitis.
Methods: The study was a retrospective cohort study, the patient’s file
was examined with the diagnosis of granulomatous mastitis. All patients
underwent tissue examination before treatment. Different therapeutic
approaches were examined. The negative pathology of the patients for
breast malignancies, or other types of mastitis and the final diagnosis
of idiopathic granulomatous mastitis according to the para clinic, were
principal conditions for admission in our study. The sample size is 44
people, due to the rarity of the disease and the limited number of
samples to be studied, sampling was carried out by the census method of
all IGM patients who were referred to the selected training and
treatment centers Results: The average age of the individuals was 37.43
± 08.7 The most common presentation was in the form of a mass in 26
patients (77%), and 26 patients (59.1%) had a history of recent
pregnancy and lactation, while 16 patients (36.4%) were using OCP (Oral
Contraceptive Pills). Ultimately, 27 patients (61.4%) were in
remission, and 6 patients (13.6%) experienced a relapse after 6 months.
Only the previous treatment showed a significant association with
complete remission, while involvement on the opposite side showed a
significant association with disease relapse after 6 months. Conclusion:
In the present study, it was found that the most common symptom among
patients was the occurrence of a mass. Furthermore, it was determined
that the type of treatment and symptoms did not have a significant
impact on the treatment outcome in terms of relapse or remission. The
only significant association observed was between previous treatment
with disease remission and the bilateral nature of symptoms with disease
relapse.