Two-dimensional Left Ventricular End-Diastolic Diameter
LVEDD had the lowest overall effect size with a standard mean difference of 0.47 (95%CI; 0.11-0.81, p≤0.01), with no significant heterogeneity (54%). Fifty percent of the studies individually demonstrated statistically significant differences in LVEDD between myocarditis populations and controls, whilst the other half did not. Importantly the two studies that demonstrated this difference, also showed a significant difference in LVEF (13, 14).