Two-dimensional Left Ventricular End-Diastolic Diameter
LVEDD had the lowest overall effect size with a standard mean difference
of 0.47 (95%CI; 0.11-0.81, p≤0.01), with no significant heterogeneity
(54%). Fifty percent of the studies individually demonstrated
statistically significant differences in LVEDD between myocarditis
populations and controls, whilst the other half did not. Importantly the
two studies that demonstrated this difference, also showed a significant
difference in LVEF (13,
14).