Three-Dimensional Measure of Left Ventricular Function
Unfortunately, there were no studies which compared 3D LVEF between patients with myocarditis and controls. Only one published study assessed 3D strain (3D STE) hence a meta-analysis was not performed to assess this parameter. In this study, 3D-STE was measured using the Vivid E9 (GE-healthcare) echocardiographic system(17). Acquisitions were performed with the highest possible frame rate and then analysed offline using EchoPAC v113 for 3D STE LV myocardial deformation. 3D LV-GLS, global area strain (GAS) and global radial strain (GRS) was calculated using average of 17 myocardial segments. 3D LV-GLS, GCS, GAS and GRS were lower in magnitude in the myocarditis group compared to controls (-11.80% vs -14.98%, p<0.0001; -12.57% vs -15.12%, p<0.001; -22.28% vs -25.87%, p<0.001; and 31.47% vs 38.06 %, p<0.0001, respectively). ROC curve analysis identified diagnostic values of 3D GLS, GCS, GAS and GRS for the diagnosis of myocarditis with AUC values of 0.78, 0.71, 0.73 and 0.70 respectively.